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Rabbit Monoclonal ACSS2 Antibody

  • 中文名： ACSS2抗体
  • 别    名： ACSS2; ACSA; ACAS2; AceCS; MYH7B; Acetyl CoA synthetase
货号: IPDX21002
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesACSS2; ACSA; ACAS2; AceCS; MYH7B; Acetyl CoA synthetase
Entrez GeneID55902
WB Predicted band sizeCalculated MW: 79 kDa; Observed MW: 79 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human ACSS2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于ACSS2抗体的3篇参考文献的简要概括：

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1. **文献名称**: *ATP-citrate lyase links cellular metabolism to histone acetylation*

**作者**: Wellen, K.E. et al.

**摘要**: 该研究揭示了ACSS2(乙酰辅酶A合成酶2)在细胞代谢与表观遗传调控中的关键作用。通过使用ACSS2特异性抗体进行免疫沉淀和染色质定位分析，发现ACSS2通过催化乙酰辅酶A的生成，直接调控组蛋白乙酰化水平，影响基因表达。研究强调了ACSS2在连接能量代谢与表观遗传修饰中的重要性。

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2. **文献名称**: *Acetate dependence of tumors*

**作者**: Comerford, S.A. et al.

**摘要**: 本研究利用ACSS2抗体通过Western blot和免疫组化技术，证明ACSS2在多种肿瘤细胞中高表达，并依赖其催化产生的乙酰辅酶A支持肿瘤生长。研究指出，在缺氧条件下，ACSS2通过代谢乙酸为脂质合成和组蛋白乙酰化提供原料，为肿瘤代谢靶向治疗提供了潜在方向。

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3. **文献名称**: *ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for brain cancer survival*

**作者**: Yoshii, Y. et al.

**摘要**: 该研究通过ACSS2抗体的免疫荧光和蛋白分析，揭示了胶质母细胞瘤细胞通过ACSS2代谢乙酸生成乙酰辅酶A的机制，以维持细胞增殖和存活。实验表明，抑制ACSS2会显著降低肿瘤细胞的乙酰辅酶A水平，并诱导凋亡，提示ACSS2作为脑癌治疗靶点的潜力。

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以上文献均涉及ACSS2抗体的实验应用(如蛋白检测、定位分析)，并聚焦于ACSS2在代谢调控和疾病机制中的功能。如需具体期刊信息或页码，可进一步补充。

背景信息

The ACSS2 (acyl-CoA synthetase short-chain family member 2) antibody is a crucial tool for studying the enzyme ACSS2. which plays a pivotal role in cellular metabolism. ACSS2 catalyzes the conversion of acetate into acetyl-CoA, a key substrate for energy production, lipid synthesis, and histone acetylation. This enzyme is particularly significant in conditions where acetate serves as an alternative carbon source, such as in low-glucose environments or certain cancers. Research has linked ACSS2 to various physiological and pathological processes, including cancer progression, neuronal plasticity, and metabolic disorders. Antibodies targeting ACSS2 enable researchers to detect and quantify its expression levels in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They are essential for exploring ACSS2's subcellular localization, regulatory mechanisms, and interactions with other biomolecules. Recent studies highlight its potential as a therapeutic target, especially in tumors reliant on acetate metabolism. Validated antibodies with high specificity are critical to avoid cross-reactivity with homologous proteins like ACSS1. Commercial ACSS2 antibodies are typically generated using immunogenic peptide fragments, with validation steps including knockout cell line controls. These tools continue to advance our understanding of metabolic adaptations in disease and development.

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