| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Angio-associated migratory cell protein |
| Entrez GeneID | 14 |
| WB Predicted band size | Calculated MW: 47 kDa; Observed MW: 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human AAMP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于AAMP(Angio-Associated Migratory Cell Protein)抗体的3篇示例性参考文献(注：部分内容为模拟概括，实际文献需通过学术数据库验证)：
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1. **文献名称**: *AAMP modulates Wnt/β-catenin signaling in colorectal cancer metastasis*
**作者**: Deng, Y., et al.
**摘要**: 研究揭示了AAMP通过调控Wnt/β-catenin信号通路促进结直肠癌细胞迁移和侵袭的机制，并开发了一种特异性AAMP抗体用于检测其在肿瘤组织中的高表达水平，为癌症治疗提供了潜在靶点。
2. **文献名称**: *Angio-Associated Migratory Cell Protein (AAMP) interacts with integrins to regulate endothelial cell motility*
**作者**: Smith, J.R., et al.
**摘要**: 本文利用AAMP抗体进行免疫共沉淀实验，发现AAMP与整合素β1亚基直接结合，调节内皮细胞迁移和血管生成，提示其在病理性血管形成中的关键作用。
3. **文献名称**: *Development of a monoclonal antibody against human AAMP for diagnostic applications in breast cancer*
**作者**: Garcia-Moreno, P., et al.
**摘要**: 研究团队开发了一种高特异性抗人AAMP单克隆抗体，验证了其在乳腺癌患者血清和组织样本中的诊断价值，发现AAMP表达水平与肿瘤分期和预后显著相关。
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**建议**：以上文献为示例，实际文献可通过 **PubMed**、**Google Scholar** 或 **Web of Science** 搜索关键词 "AAMP antibody"、"Angio-Associated Migratory Cell Protein" 获取。如需具体文章，可补充说明研究方向(如癌症、血管生成等)以便进一步筛选。
AAMP (Angio-Associated Migratory Cell Protein) is a conserved 52-kDa protein initially identified for its role in cell migration and angiogenesis. It is expressed in various tissues, including endothelial cells, leukocytes, and certain cancer cells. AAMP interacts with integrins, chemokine receptors, and cytoskeletal components, regulating cell adhesion, motility, and signaling pathways such as Rho GTPases. Its involvement in vascular remodeling and immune cell trafficking links it to pathologies like cancer metastasis, chronic inflammation, and cardiovascular diseases.
AAMP antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blot, immunofluorescence, and immunohistochemistry. Commercial AAMP antibodies are typically raised against specific epitopes, such as recombinant human AAMP fragments or synthetic peptides. Validation includes verifying reactivity in knockdown models or tissue-specific expression patterns. Research using these antibodies has highlighted AAMP's potential as a biomarker in tumor progression and a therapeutic target for inhibiting pathological angiogenesis or inflammatory responses. However, variability in antibody specificity necessitates careful experimental controls to ensure data reliability.
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