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Rabbit Monoclonal NLRP3 Antibody

  • 中文名： NLRP3抗体
  • 别    名： FCU; MWS; FCAS; Cias1; Mmig1; NLRP3; Pypaf1; AII/AVP; AGTAVPRL; Cryopyrin
货号: IPDX20972
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFCU; MWS; FCAS; Cias1; Mmig1; NLRP3; Pypaf1; AII/AVP; AGTAVPRL; Cryopyrin
Entrez GeneID114548
WB Predicted band sizeCalculated MW: 118 kDa; Observed MW: 118 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of human NLRP3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于NLRP3抗体的重要参考文献(虚构示例，仅供格式参考)：

1. **标题**: *Targeting NLRP3 inflammasome activation in inflammatory diseases*

**作者**: Schroder K, et al.

**摘要**: 综述NLRP3炎症小体在类风湿性关节炎和阿尔茨海默病中的激活机制，提出单克隆抗体阻断NLRP3蛋白组装可抑制IL-1β释放，为治疗提供新策略。

2. **标题**: *A human anti-NLRP3 antibody attenuates inflammation in murine sepsis models*

**作者**: Coll RC, et al.

**摘要**: 开发人源化NLRP3单抗CP-456.773.通过体外实验证明其特异性结合NLRP3的NACHT结构域，并在脓毒症小鼠模型中显著降低血清IL-18水平，改善生存率。

3. **标题**: *Structural basis for NLRP3 inhibition by nanobodies*

**作者**: Huang Y, et al.

**摘要**: 利用冷冻电镜解析NLRP3与纳米抗体的复合物结构，发现抗体通过稳定NLRP3自抑制构象阻止炎症小体激活，为理性化抗体设计提供结构依据。

4. **标题**: *NLRP3-blocking antibody reduces fibrosis in NASH progression*

**作者**: Wree A, et al.

**摘要**: 在非酒精性脂肪性肝炎小鼠模型中，抗NLRP3抗体通过抑制caspase-1活化和肝星状细胞活化，显著减轻肝脏炎症和纤维化程度。

注：以上文献信息为模拟生成，实际文献需通过PubMed/Web of Science检索关键词"NLRP3 antibody"、"NLRP3 inhibitor"获取。建议重点参考Nature Immunology、Immunity等期刊近年高被引论文。

背景信息

NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is a critical component of the NLRP3 inflammasome, a multiprotein complex that regulates innate immune responses by activating caspase-1 and promoting the secretion of pro-inflammatory cytokines like IL-1β and IL-18. Dysregulation of NLRP3 has been implicated in various inflammatory and autoimmune diseases, including gout, Alzheimer’s disease, atherosclerosis, and type 2 diabetes. NLRP3 antibodies are essential tools for studying the expression, localization, and activation mechanisms of this protein in both physiological and pathological contexts. Researchers use these antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate NLRP3’s role in disease pathways or to evaluate therapeutic interventions targeting the inflammasome. Additionally, NLRP3 antibodies have potential therapeutic applications, with some monoclonal antibodies in development to specifically inhibit aberrant NLRP3 activity. However, challenges remain in ensuring antibody specificity due to structural similarities among NLR family members and post-translational modifications of NLRP3. Despite these hurdles, NLRP3 antibodies continue to advance our understanding of inflammasome biology and contribute to the discovery of novel anti-inflammatory therapies.

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