| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Anterior gradient protein 2 homolog; AG-2; hAG-2; HPC8; Secreted cement gland protein XAG-2 homolog; AGR2; AG2; GOB4; XAG2 |
| Entrez GeneID | 10551 |
| WB Predicted band size | Calculated MW: 20 kDa; Observed MW: 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human Anterior Gradient 2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 **Anterior Gradient 2 (AGR2)** 抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *AGR2 antibodies: Potent tools for biomarker discovery in cancer and autoimmune diseases*
**作者**: Li X, et al.
**摘要**: 该研究开发了一种高特异性单克隆抗体，用于检测组织及血清中的AGR2蛋白。实验表明，该抗体在乳腺癌和结直肠癌样本中显著标记AGR2过表达，并验证了其作为癌症生物标志物的潜力。
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2. **文献名称**: *Anterior Gradient 2蛋白在胰腺导管腺癌中的表达及其抗体在诊断中的应用*
**作者**: Zhang Y, et al.
**摘要**: 研究利用抗AGR2抗体进行免疫组化分析，发现AGR2在胰腺癌组织中高表达，且与患者预后不良相关。抗体检测可辅助胰腺癌的早期诊断和病理分级。
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3. **文献名称**: *AGR2 modulates immune response through antibody-mediated extracellular pathway regulation*
**作者**: Park S, et al.
**摘要**: 通过抗AGR2抗体阻断实验，揭示了AGR2通过调控内质网应激和细胞外基质信号影响肿瘤微环境中的免疫逃逸机制，为靶向治疗提供新思路。
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The Anterior Gradient 2 (AGR2) protein, encoded by the *AGR2* gene, is a member of the protein disulfide isomerase (PDI) family involved in endoplasmic reticulum stress responses, cell signaling, and tissue homeostasis. It plays roles in cell adhesion, migration, and cancer progression, with overexpression observed in various cancers, including breast, prostate, and gastrointestinal malignancies. AGR2 is also implicated in inflammatory diseases and wound healing.
AGR2 antibodies are essential tools for detecting and quantifying AGR2 expression in research and diagnostics. They are widely used in techniques like immunohistochemistry, Western blotting, and ELISA to study AGR2's role in tumorigenesis, metastasis, and drug resistance. Specific monoclonal or polyclonal antibodies target distinct epitopes, enabling researchers to explore AGR2 interactions with pathways like EGFR, HER2. and the unfolded protein response.
Clinically, AGR2 antibodies aid in identifying cancer biomarkers or therapeutic targets. Some studies suggest AGR2's extracellular secretion in tumors makes it a potential target for antibody-based therapies. However, its dual roles (pro-tumor vs. tumor-suppressive in certain contexts) and cross-reactivity with homologous proteins (e.g., AGR3) require careful antibody validation. Commercial AGR2 antibodies vary in specificity, emphasizing the need for rigorous controls in experimental design.
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