| WB | 咨询技术 | Rat |
| IF | 咨询技术 | Rat |
| IHC | 1/50-1/100 | Rat |
| ICC | 技术咨询 | Rat |
| FCM | 咨询技术 | Rat |
| Elisa | 咨询技术 | Rat |
| Aliases | THY1; Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD antigen CD90 |
| Entrez GeneID | 7070 |
| WB Predicted band size | Calculated MW: 18 kDa; Observed MW: 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Rat |
| Immunogen | A synthetic peptide of human CD90 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于CD90抗体的3篇代表性文献示例(内容为虚构，仅供参考)：
---
1. **文献名称**：CD90 as a Functional Marker for Isolation of Liver Cancer Stem Cells
**作者**：Wang X, et al.
**摘要**：本研究利用抗CD90抗体从肝癌组织中分离出CD90+细胞亚群，证实其具有自我更新和耐药特性。抗体阻断实验显示CD90通过Wnt/β-catenin通路促进肿瘤侵袭，提示其作为治疗靶点的潜力。
2. **文献名称**：Thy-1 (CD90) Antibody Attenuates Fibrosis in Pulmonary Fibrosis Models
**作者**：Smith JL, et al.
**摘要**：通过抗CD90抗体靶向抑制成纤维细胞表面Thy-1.显著降低TGF-β1介导的胶原沉积，为肺纤维化的抗体疗法提供了实验依据。
3. **文献名称**：CD90 Antibody-Based Sorting Enhances Neural Stem Cell Regeneration Capacity
**作者**：Garcia R, et al.
**摘要**：研究采用CD90抗体分选小鼠神经干细胞，发现CD90+细胞具有更强的神经突延伸和损伤修复能力，提示其在神经再生治疗中的应用价值。
---
注：实际文献需通过PubMed(https://pubmed.ncbi.nlm.nih.gov)或Google Scholar检索关键词“CD90 antibody”、“Thy-1 antibody”获取。
CD90 (Thy-1) is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein belonging to the immunoglobulin superfamily. First identified as a thymocyte antigen in mice, it is widely expressed across species, including humans, and plays diverse roles in cell adhesion, migration, signaling, and apoptosis regulation. CD90 is notably present on stem cells (e.g., mesenchymal stem cells), neurons, fibroblasts, activated endothelial cells, and certain leukemia cells, though its expression varies by tissue and developmental stage.
CD90 antibodies are critical tools for identifying and isolating CD90-expressing cell populations, particularly in stem cell research and cancer biology. In regenerative medicine, these antibodies help characterize mesenchymal stem cells, which are CD90-positive and crucial for tissue repair. In oncology, CD90 has been implicated in tumor progression, metastasis, and cancer stem cell maintenance, making it a potential therapeutic target or biomarker. For example, CD90 is overexpressed in subsets of leukemias, gliomas, and hepatocellular carcinomas.
Structurally, CD90 antibodies target its extracellular Ig-like domain, enabling applications in flow cytometry, immunohistochemistry, and functional studies. Recent research also explores CD90's role in modulating immune responses and fibrosis, highlighting its dual pro- and anti-inflammatory effects depending on context. Despite its widespread use, CD90's precise molecular mechanisms remain partially elusive, driving ongoing investigations into its ligand interactions and signaling pathways. Overall, CD90 antibodies remain indispensable for both basic research and translational studies in stem cell therapy, cancer, and immunology.
×
