| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EDSC; EDSCL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human COL5A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与Cytokeratin 16(CK16)抗体相关的文献示例，基于典型研究方向整理：
1. **"Keratin 16 expression correlates with keratinocyte activation and psoriasis pathogenesis"**
*Leigh, I.M., et al. (1995)*
摘要：该研究通过免疫组化发现CK16在银屑病皮损中显著上调，提示其与表皮过度增殖和异常分化相关，可作为银屑病病理标志物。
2. **"Cytokeratin 16 as a biomarker of epithelial dysplasia in oral squamous cell carcinoma"**
*Paladini, R., et al. (1996)*
摘要：通过抗CK16抗体检测头颈部鳞癌组织，发现其高表达与肿瘤侵袭性和不良预后相关，提示其在癌症进展中的潜在诊断价值。
3. **"Dynamic expression of keratin 16 during epidermal wound healing"**
*Mansbridge, J.N., & Knapp, A.M. (1987)*
摘要：研究使用CK16抗体追踪皮肤伤口修复过程，发现其在迁移性角质形成细胞中特异性表达，表明其参与上皮再生调控。
注：以上为模拟摘要，实际文献需通过PubMed或学术数据库检索确认。建议使用关键词 **"Keratin 16 antibody" "KRT16 immunohistochemistry"** 查找最新研究。
Cytokeratin 16 (CK16) is a type I intermediate filament protein belonging to the keratin family, primarily expressed in stratified epithelial tissues. It plays a critical role in maintaining cellular structural integrity and regulating mechanical stress resilience. CK16 is typically found in hyperproliferative or activated keratinocytes, distinguishing it from other keratins that are constitutively expressed in differentiated epithelia. Its expression is closely associated with dynamic epithelial remodeling, such as during wound healing, inflammation, or pathological states like psoriasis, cancer, and certain genetic skin disorders (e.g., pachyonychia congenita).
Antibodies targeting CK16 are widely used as research tools to study epithelial proliferation and differentiation. In diagnostics, CK16 immunostaining helps identify activated keratinocytes in tissue samples, serving as a marker for hyperproliferative skin diseases or tumor progression. For instance, elevated CK16 levels are observed in squamous cell carcinomas and precancerous lesions, reflecting its link to abnormal cell cycle regulation. Additionally, CK16 antibodies aid in exploring the molecular mechanisms of epithelial barrier dysfunction and chronic inflammatory conditions. Recent studies also highlight its potential role in modulating immune responses within the skin microenvironment. Despite its specificity, CK16 expression can overlap with other stress-induced keratins (e.g., CK6), necessitating careful interpretation in experimental and clinical contexts. Overall, CK16 antibodies remain vital for understanding epithelial biology and disease pathogenesis.
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