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Rabbit Monoclonal GlycophorinC Antibody

  • 中文名： Glycophorin C抗体
  • 别    名： GYPC; CD236; CD236R; GE; GPC; GYPD
货号: IPDX20905
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGYPC; CD236; CD236R; GE; GPC; GYPD
Entrez GeneID2995
WB Predicted band sizeCalculated MW: 14 kDa; Observed MW: 43 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human Glycophorin C
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于Glycophorin C抗体的代表性文献摘要信息(注：文献为示例性内容，实际引用需核实)：

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1. **文献名称**: "Monoclonal antibodies to glycophorin C reveal the presence of a protein complex in the erythrocyte membrane"

**作者**: Mueller T.J., Morrison M.

**摘要**: 该研究通过单克隆抗体技术识别了红细胞膜中的Glycophorin C，发现其与4.1R蛋白形成复合物，对维持红细胞膜机械稳定性起关键作用，并可能参与遗传性椭圆红细胞增多症的病理机制。

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2. **文献名称**: "Role of glycophorin C in Plasmodium falciparum erythrocyte invasion"

**作者**: Lobo C.A., et al.

**摘要**: 本文探讨了Glycophorin C作为疟原虫(恶性疟原虫)入侵红细胞的潜在受体。通过抗体阻断实验，发现抗Glycophorin C抗体能部分抑制疟原虫对红细胞的侵袭，提示其在疟疾感染中的功能意义。

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3. **文献名称**: "Antibody-mediated detection of glycophorin C variants in hereditary elliptocytosis"

**作者**: Dhermy D., et al.

**摘要**: 研究利用特异性抗体分析Glycophorin C的遗传变异，发现某些突变体与4.1R蛋白结合缺陷相关，导致红细胞膜脆性增加，为遗传性椭圆红细胞增多症的分子诊断提供了抗体检测方法。

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如需具体文献，建议通过PubMed或Google Scholar以关键词“Glycophorin C antibody”或“Glycophorin C monoclonal antibody”检索近年研究。

背景信息

Glycophorin C (GPC), encoded by the *GYPC* gene, is a minor sialoglycoprotein expressed on the surface of human erythrocytes. It plays a critical role in maintaining membrane mechanical stability by interacting with the cytoskeletal protein 4.1R. GPC is also a carrier for the Gerbich blood group antigens (Ge), which include high-frequency (Ge2. Ge3. Ge4) and low-frequency (Ge1. Ge5–Ge13) epitopes. Antibodies targeting Glycophorin C are primarily relevant in transfusion medicine and hematology. Naturally occurring anti-Ge antibodies are rare but can cause hemolytic transfusion reactions or hemolytic disease of the fetus/newborn (HDFN) in individuals lacking specific Gerbich antigens. Clinically significant anti-GPC antibodies are typically IgG and may arise following exposure through transfusion or pregnancy. In research, GPC antibodies are utilized to study red cell membrane disorders, such as hereditary elliptocytosis or Southeast Asian ovalocytosis, where GPC-4.1R interactions are disrupted. Monoclonal anti-GPC antibodies (e.g., BRIC4. BRIC10) are commonly employed in blood typing, immunoassays, and flow cytometry to characterize erythrocyte membrane integrity or diagnose Ge antigen variants. Recent studies also explore GPC's role as a receptor for *Plasmodium falciparum* erythrocyte-binding antigen 140 (EBA-140) in malaria pathogenesis, highlighting its broader biomedical significance.

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