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Rabbit Monoclonal ALDH1A1 Antibody

  • 中文名： ALDH1A1抗体
  • 别    名： ALDH1A1; ALDC; ALDH1; PUMB1; Retinal dehydrogenase 1; RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase; cytosolic
货号: IPDX20898
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesALDH1A1; ALDC; ALDH1; PUMB1; Retinal dehydrogenase 1; RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase; cytosolic
Entrez GeneID216
WB Predicted band sizeCalculated MW: 55 kDa; Observed MW: 55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthetic peptide of human ALDH1A1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于ALDH1A1抗体的参考文献摘要示例(文献标题与作者为虚构示例，仅供格式参考)：

1. **文献名称**：ALDH1A1 as a Functional Marker of Breast Cancer Stem Cells

**作者**：Clarke, M.F. et al.

**摘要**：本研究验证了ALDH1A1抗体在乳腺癌干细胞鉴定中的应用，发现ALDH1A1高表达细胞具有自我更新和成瘤能力，提示其作为癌症干细胞标志物的临床价值。

2. **文献名称**：ALDH1A1 Expression Predicts Hepatocellular Carcinoma Prognosis

**作者**：Matsumoto, K. et al.

**摘要**：通过免疫组化分析ALDH1A1抗体标记的肝癌组织样本，证实ALDH1A1过表达与患者总生存期缩短及化疗耐药显著相关。

3. **文献名称**：ALDH1A1 Antibody-Based Flow Cytometry for Stem Cell Isolation

**作者**：Hess, D.A. et al.

**摘要**：开发了一种基于ALDH1A1抗体的流式分选技术，成功从小鼠骨髓中分离出高纯度造血干细胞，并验证其再生潜力。

*注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词“ALDH1A1 antibody”获取。*

背景信息

The ALDH1A1 antibody is a crucial tool in biomedical research, targeting aldehyde dehydrogenase 1 family member A1. a key enzyme in cellular detoxification and retinoic acid biosynthesis. ALDH1A1 oxidizes toxic aldehydes to carboxylic acids, playing roles in stem cell maintenance, oxidative stress response, and cancer progression. Its overexpression is associated with cancer stem cells (CSCs), chemotherapy resistance, and poor prognosis in malignancies like breast, lung, and ovarian cancers. Researchers use ALDH1A1 antibodies primarily to detect protein expression and localization via techniques including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These applications help identify CSC populations in tumors, study differentiation pathways, and evaluate ALDH1A1's role in metabolic disorders and neurodegenerative diseases. Commercial ALDH1A1 antibodies are typically raised in rabbits or mice, available as monoclonal or polyclonal variants with validation in specific experimental models. Recent studies also explore its potential as a therapeutic target, driving interest in drug development against ALDH1A1-positive resistant cancer cells. Proper validation using positive/negative controls and knockout validation is essential due to occasional cross-reactivity with other ALDH isoforms. This antibody continues to bridge mechanistic studies and clinical applications in precision oncology.

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