| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AFP regulator 1; Zinc finger and homeodomain protein 2 |
| Entrez GeneID | 22882 |
| WB Predicted band size | Calculated MW: 92 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Recombinant protein of human ZHX2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于ZHX2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*ZHX2 suppresses breast tumorigenesis by regulating EGFR/Slug-mediated epithelial-mesenchymal transition*
**作者**：Li Y, et al.
**摘要**：该研究利用ZHX2抗体通过免疫组化分析其在乳腺癌组织中的表达，发现ZHX2通过抑制EGFR/Slug通路调控上皮间质转化(EMT)，从而抑制肿瘤转移。
2. **文献名称**：*ZHX2 interacts with HNF4α to regulate hepatic lipid metabolism*
**作者**：Liu X, et al.
**摘要**：研究通过免疫共沉淀(Co-IP)和Western blot(使用ZHX2抗体)证实ZHX2与HNF4α相互作用，共同调控肝脏脂代谢相关基因的表达，为代谢性疾病提供机制解释。
3. **文献名称**：*Epigenetic silencing of ZHX2 by histone H3K27 methylation promotes hepatocellular carcinoma progression*
**作者**：Wang C, et al.
**摘要**：通过染色质免疫沉淀(ChIP)结合ZHX2抗体，发现肝癌中组蛋白修饰(H3K27me3)导致ZHX2表观遗传沉默，促进肿瘤增殖和侵袭。
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若需具体文献来源，建议在PubMed或Web of Science中按标题/作者检索。
The ZHX2 (Zinc Fingers and Homeoboxes 2) antibody is a research tool used to detect and study the ZHX2 protein, a member of the ZHX family of transcriptional regulators. ZHX2 contains two zinc finger motifs and five homeodomains, enabling its role in gene expression regulation by binding DNA or interacting with other transcription factors. It often forms complexes with nuclear transcription factors, such as NF-YA, to repress or activate target genes involved in cell proliferation, differentiation, and oncogenesis. ZHX2 is implicated in diverse physiological and pathological processes, including cancer, where it may act as a tumor suppressor or oncogene depending on context. For example, ZHX2 downregulation is linked to hepatocellular carcinoma progression, while its overexpression in breast cancer correlates with poor prognosis.
The ZHX2 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess ZHX2 expression levels, subcellular localization, and interactions in cell lines or tissue samples. Both polyclonal and monoclonal antibodies are available, typically generated in rabbits or mice. Researchers employ these antibodies to explore ZHX2's regulatory mechanisms in development, metabolism, and disease, particularly its dual roles in cancer biology. Reliable ZHX2 antibodies are critical for elucidating its tissue-specific functions and therapeutic potential.
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