| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AGS1; AGS5; CRV; DNase III; DRN3; HERNS; TREX1 |
| Entrez GeneID | 11277 |
| WB Predicted band size | Calculated MW: 33 kDa; Observed MW: 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human TREX1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于TREX1抗体的3篇参考文献及其摘要概括：
1. **"Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome"**
- **作者**: Crow, Y.J., et al.
- **摘要**: 该研究首次发现TREX1基因突变与Aicardi-Goutières综合征(AGS)的关联，利用TREX1抗体检测患者细胞中TREX1蛋白的表达缺失，揭示了其在清除细胞质DNA中的关键作用及突变导致的自身免疫反应异常。
2. **"TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner"**
- **作者**: Stetson, D.B., et al.
- **摘要**: 研究通过TREX1抗体验证基因敲除细胞系中蛋白的缺失，证明TREX1缺陷会激活cGAS-STING通路，导致I型干扰素信号异常，为自身免疫疾病机制提供了分子基础。
3. **"TREX1 knockout mice exhibit progressive cardiomyopathy due to chronic activation of innate immune signaling"**
- **作者**: Grieves, J.L., et al.
- **摘要**: 利用TREX1抗体分析基因敲除小鼠模型，发现TREX1缺失引发心肌细胞DNA损伤累积和持续干扰素应答，最终导致心肌病，提示TREX1在维持心脏稳态中的作用。
4. **"Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease"**
- **作者**: Ahn, J., et al.
- **摘要**: 研究通过TREX1抗体检测非造血细胞中TREX1功能异常，发现其通过干扰素信号驱动系统性自身免疫，为靶向治疗提供了潜在方向。
以上文献均涉及TREX1抗体的实验应用(如Western blot、免疫组化)，用于验证蛋白表达或功能缺失，并关联其与自身免疫疾病的机制。
TREX1 (Three-prime repair exonuclease 1) is a DNA exonuclease encoded by the *TREX1* gene, primarily involved in degrading cytoplasmic DNA to prevent aberrant immune activation. Mutations in *TREX1* are linked to autoimmune and inflammatory disorders, such as Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus (SLE), due to accumulated DNA triggering type I interferon responses.
TREX1 antibodies refer to two distinct categories: **1)** Antibodies targeting the TREX1 protein, used as research tools to study its expression, localization, and function in DNA repair and immune regulation. These antibodies aid in detecting TREX1 in assays like Western blot, immunohistochemistry, or immunofluorescence. **2)** Autoantibodies against TREX1. found in some autoimmune conditions. Their role remains unclear but may correlate with disease severity or specific clinical features.
Research on TREX1 antibodies focuses on elucidating TREX1’s mechanisms in genome stability and autoimmunity, as well as exploring diagnostic or therapeutic applications. For instance, detecting anti-TREX1 autoantibodies could serve as a biomarker, while modulating TREX1 activity or targeting its pathways may offer therapeutic strategies for autoimmune diseases. Current studies emphasize understanding how TREX1 dysfunction or autoantibodies contribute to pathological processes, bridging gaps between DNA metabolism defects and immune dysregulation.
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