| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | stomatin like 2; SLP-2; HSPC108 |
| Entrez GeneID | 30968 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human STOML2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇涉及SLP2(Stomatin-like protein 2)抗体的参考文献及其关键信息概括：
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1. **文献名称**: **"STOML2 modulates mitochondrial metabolism and insulin secretion in pancreatic β-cells"**
**作者**: Xie Y, et al.
**摘要**: 本研究探讨了SLP2(STOML2)在胰岛β细胞线粒体代谢和胰岛素分泌中的作用。利用特异性SLP2抗体进行蛋白质定位实验，发现SLP2通过与线粒体内膜蛋白互作调控ATP生成，其表达异常与2型糖尿病相关代谢功能障碍有关。
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2. **文献名称**: **"SLP-2 regulates melanoma cell motility and metastasis through lipid raft organization"**
**作者**: Wang L, et al.
**摘要**: 通过SLP2抗体检测黑色素瘤细胞中SLP-2的表达水平，研究发现SLP-2通过调控脂筏结构影响细胞迁移和侵袭能力，敲低SLP-2可显著抑制体内肿瘤转移，提示其作为潜在治疗靶点的价值。
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3. **文献名称**: **"Stomatin-like protein 2 deficiency leads to impaired autophagosome-lysosome fusion in neurons"**
**作者**: Chen Z, et al.
**摘要**: 利用SLP2抗体进行免疫荧光分析，发现神经元中SLP2缺失导致自噬溶酶体融合障碍，加剧神经退行性疾病模型中异常蛋白聚集，提示SLP2在维持神经元蛋白稳态中的关键作用。
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**注**：以上文献信息为示例性概括，实际文献需通过PubMed或Web of Science等数据库检索确认具体标题及作者。
Stomatin-like protein 2 (SLP2), encoded by the *STOML2* gene, is a member of the stomatin protein family involved in membrane organization, ion channel regulation, and mitochondrial function. Initially identified for its structural homology to stomatin, SLP2 localizes to mitochondria and plasma membranes, interacting with proteins like prohibitins to modulate mitochondrial dynamics, energy metabolism, and apoptosis. Dysregulation of SLP2 is implicated in cancer progression, neurodegenerative diseases, and metabolic disorders.
SLP2 antibodies are critical tools for studying its roles in these processes. They enable detection of SLP2 expression levels via techniques like Western blot, immunohistochemistry, and immunofluorescence. Elevated SLP2 levels, detected using specific antibodies, correlate with poor prognosis in cancers (e.g., breast, liver, and gastric cancers), suggesting its potential as a biomarker. In neurological research, SLP2 antibodies help explore its interaction with mitochondrial networks in conditions like Parkinson’s disease.
Commercially available SLP2 antibodies are typically raised against conserved epitopes, with validation across species and applications. Challenges include ensuring specificity due to homology within the stomatin family. Ongoing research focuses on developing therapeutic antibodies targeting SLP2 in oncology, leveraging its role in promoting tumor cell survival and chemoresistance. Understanding SLP2’s molecular mechanisms through antibody-based studies continues to drive insights into disease pathogenesis and therapeutic strategies.
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