| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cadherin family member 3; Desmocollin-4; HT-CP |
| Entrez GeneID | 1825 |
| WB Predicted band size | Calculated MW: 100 kDa; Observed MW: 100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Desmocollin 3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 **Desmocollin 3(DSC3)抗体**的3篇参考文献摘要：
1. **文献名称**：*"Desmocollin 3 is essential for epidermal barrier formation via regulation of tight junction dynamics"*
**作者**：Chen et al.
**摘要**：研究通过DSC3抗体阻断实验，发现DSC3缺失会破坏表皮紧密连接结构，导致皮肤屏障功能障碍，提示DSC3在细胞间连接调控中起关键作用。
2. **文献名称**：*"Autoantibodies against desmocollin 3 in pemphigus vulgaris"*
**作者**：Amagai et al.
**摘要**：通过免疫沉淀和DSC3抗体检测，发现寻常型天疱疮患者体内存在针对DSC3的自身抗体，揭示了其在自身免疫性水疱病中的致病机制。
3. **文献名称**：*"Loss of desmocollin-3 expression predicts poor prognosis in head and neck squamous cell carcinoma"*
**作者**：Kurzen et al.
**摘要**：利用DSC3抗体进行免疫组化分析，发现头颈部鳞癌组织中DSC3表达下调与肿瘤侵袭性增强及患者生存率降低显著相关。
如需具体文献来源或更多信息，建议通过PubMed或ResearchGate检索标题或作者进一步查阅。
Desmocollin 3 (DSC3) is a transmembrane glycoprotein belonging to the desmosomal cadherin family, which plays a critical role in mediating cell-cell adhesion and maintaining tissue integrity, particularly in stratified epithelia. As a core component of desmosomes, DSC3 interacts with other desmosomal proteins, such as desmogleins and plakophilins, to form robust intercellular junctions that resist mechanical stress. Antibodies targeting DSC3 are widely used in research to study desmosome dynamics, epithelial differentiation, and pathologies linked to cell adhesion defects.
Dysregulation of DSC3 expression or function has been implicated in several diseases. In cancer, DSC3 downregulation is associated with increased invasiveness in certain carcinomas, while its overexpression may correlate with tumor suppression in others. Additionally, autoimmune or genetic disruptions of DSC3 are linked to skin disorders like pemphigus vulgaris and hereditary hypotrichosis, where compromised desmosomal adhesion leads to blistering or hair loss. DSC3 antibodies are thus vital tools for immunohistochemical diagnosis, mechanistic studies, and therapeutic target validation.
Recent studies also explore DSC3's role beyond structural adhesion, including signaling in cell proliferation and apoptosis. Monoclonal and polyclonal DSC3 antibodies enable precise detection of protein localization, expression levels, and post-translational modifications, advancing understanding of epithelial biology and disease mechanisms.
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