| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABC38; ABCE1; HuHP68; OABP; RLI; RNASEL1; RNASELI; RNS4I |
| Entrez GeneID | 6059 |
| WB Predicted band size | Calculated MW: 67 kDa; Observed MW: 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human ABCE1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于ABCE1抗体的3-4篇参考文献的简要总结：
1. **文献名称**：*ABCE1: A link between antiviral innate immunity and the ribosome*
**作者**：Hao W. et al.
**摘要**：本研究揭示了ABCE1在干扰素信号通路中的关键作用，通过其抗体证实了其在抗病毒免疫中与核糖体循环的关联，尤其在抑制HIV-1复制中的功能。
2. **文献名称**：*Structural and functional characterization of ABCE1 in ribosome recycling*
**作者**：Kerr E.M. et al.
**摘要**：利用ABCE1特异性抗体进行免疫印迹和免疫荧光实验，验证了ABCE1在真核生物核糖体解离中的生化机制，并分析了其结构域功能。
3. **文献名称**：*ABCE1 overexpression correlates with tumor progression and drug resistance in colorectal cancer*
**作者**：Tsuchiya H. et al.
**摘要**：通过免疫组化及Western blot分析ABCE1抗体标记的样本，发现ABCE1在结直肠癌中高表达，且与化疗耐药性和预后不良相关。
4. **文献名称**：*Development and validation of a monoclonal antibody specific for human ABCE1*
**作者**：Wang L. et al.
**摘要**：报道了一种高特异性ABCE1单克隆抗体的开发，验证了其在流式细胞术和免疫共沉淀中的应用，为ABCE1功能研究提供了可靠工具。
注：上述文献信息为示例性内容，具体发表信息需根据实际文献调整。建议通过PubMed或Google Scholar以关键词“ABCE1 antibody”或“ABCE1 function”检索最新研究。
**Background of ABCE1 Antibody**
The ATP-binding cassette sub-family E member 1 (ABCE1), also known as RNase L inhibitor (RLI), is a conserved eukaryotic protein belonging to the ATP-binding cassette (ABC) transporter family. Unlike most ABC proteins, ABCE1 lacks transmembrane domains and is not involved in substrate transport. Instead, it plays essential roles in cellular processes such as ribosome biogenesis, translation termination, and antiviral immunity. ABCE1 binds to ribosomes and facilitates the recycling of ribosome subunits after translation, ensuring efficient protein synthesis. Additionally, it interacts with RNase L to modulate the innate immune response against viral infections.
ABCE1 antibodies are immunological tools designed to detect and study the expression, localization, and function of ABCE1 in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ABCE1's role in diseases, including cancer, viral infections, and neurodevelopmental disorders. Studies have shown that ABCE1 is overexpressed in certain cancers, correlating with poor prognosis, and its inhibition may impair viral replication (e.g., HIV-1).
Research utilizing ABCE1 antibodies has also highlighted its evolutionary conservation and critical involvement in embryonic development. As a dual-function protein bridging translation and immune regulation, ABCE1 remains a focus in understanding cellular homeostasis and therapeutic targeting.
×
