| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | exo/endonuclease G; ENGL; ENGLA; ENGLB; ENGL-a; ENGL-b; ENDOGL1; ENDOGL2 |
| Entrez GeneID | 9941 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human ENDOGL1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于ENDOGL1(假设为Endoglin，即ENG)抗体的示例参考文献，结构包括文献名称、作者及摘要概括(注：以下内容为示例，实际文献需通过学术数据库查询)：
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1. **"Endoglin Expression in Tumor Vasculature as a Potential Therapeutic Target"**
- **作者**: García-Castro, J., et al.
- **摘要**: 研究通过Endoglin抗体检测肿瘤血管内皮细胞中的Endoglin表达，发现其在结直肠癌中高表达，提示其作为抗血管生成治疗的靶点潜力。
2. **"Role of Endoglin in Hereditary Hemorrhagic Telangiectasia (HHT)"**
- **作者**: Shovlin, C.L., et al.
- **摘要**: 利用Endoglin特异性抗体分析HHT患者血管异常，证实ENG基因突变导致Endoglin功能缺失，影响TGF-β信号通路及血管稳定性。
3. **"Endoglin Antibody-Based Imaging for Atherosclerotic Plaque Detection"**
- **作者**: Li, X., & Zhang, Y.
- **摘要**: 开发一种新型Endoglin抗体偶联造影剂，成功在小鼠模型中实现动脉粥样硬化斑块的无创成像，显示其在心血管疾病诊断中的应用前景。
4. **"Endoglin as a Biomarker in Preeclampsia: Insights from Antibody-Based Assays"**
- **作者**: Roberts, J.M., et al.
- **摘要**: 通过ELISA和免疫组化检测孕妇血清及胎盘Endoglin水平，发现其升高与子痫前期病理相关，提示可作为妊娠并发症的预测标志物。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词(如"Endoglin antibody" + "应用领域")获取最新研究。
**Background of ENDOGL1 Antibody**
The ENDOGL1 (Endonuclease G-like 1) antibody targets a protein associated with DNA repair and apoptosis. ENDOGL1. also termed *EXOG* (Exonuclease G), is a mitochondrial endo/exonuclease involved in maintaining mitochondrial genome integrity by repairing oxidative DNA damage. It plays a role in base excision repair (BER) and is critical for processing RNA primers during mitochondrial DNA replication. Dysregulation of ENDOGL1 has been linked to mitochondrial dysfunction, contributing to neurodegenerative diseases, cancer, and aging-related pathologies.
Antibodies against ENDOGL1 are widely used in research to study its expression, localization, and function in cellular models. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein levels in tissues or cultured cells, particularly under conditions of oxidative stress or DNA damage. Commercial ENDOGL1 antibodies are typically validated for specificity in human, mouse, or rat samples, aiding mechanistic studies on mitochondrial DNA metabolism.
Recent studies highlight ENDOGL1's dual role in promoting cell survival via DNA repair or triggering apoptosis under severe damage, making it a potential therapeutic target. Its antibody serves as a key tool for exploring these pathways in disease contexts.
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