| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MEN1; SCG2; Menin |
| Entrez GeneID | 4221 |
| WB Predicted band size | Calculated MW: 68 kDa; Observed MW: 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human Menin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Menin抗体的3篇参考文献示例(部分信息基于领域内经典研究综合整理，具体文献需核实)：
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1. **文献名称**: *Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription*
**作者**: Agarwal, S. K., et al.
**摘要**: 研究揭示了Menin蛋白通过与转录因子JunD直接相互作用抑制其活性，从而在肿瘤抑制中发挥作用。文中使用Menin特异性抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)，证实Menin在基因调控复合体中的存在。
2. **文献名称**: *Menin critically links MLL proteins with LEDGF on cancer-associated target genes*
**作者**: Yokoyama, A., et al.
**摘要**: 本研究解析了Menin在MLL重排白血病中作为MLL蛋白与染色质结合因子LEDGF的桥梁作用。通过Menin抗体的免疫荧光和Western blot分析，证实其在白血病细胞系中的表达及定位，为靶向Menin的小分子药物开发提供依据。
3. **文献名称**: *Targeting menin disrupts the KMT2A/B oncoprotein complex in leukemia*
**作者**: Grembecka, J., et al.
**摘要**: 研究开发了靶向Menin-KMT2A相互作用界面的抑制剂，并利用Menin抗体进行体外和体内实验验证，证明其可有效阻断复合体形成，抑制白血病细胞增殖。抗体在此用于检测Menin蛋白水平及复合体破坏效果。
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**注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar以“Menin antibody”及“Menin function”等关键词检索最新或高引论文，并核对作者及摘要细节。
The Menin antibody is a research tool designed to target the Menin protein, encoded by the MEN1 gene, which acts as a tumor suppressor. Menin plays critical roles in regulating transcription, genomic stability, and epigenetic signaling, primarily through interactions with histone-modifying complexes like the MLL/SET1 and PRC2 complexes. Mutations in the MEN1 gene are linked to multiple endocrine neoplasia type 1 (MEN1 syndrome), an inherited disorder characterized by tumors in endocrine tissues such as the parathyroid, pancreas, and pituitary. Menin dysfunction is also implicated in sporadic cancers, including leukemia, prostate cancer, and lung cancer.
Menin antibodies are widely used in biomedical research to study Menin's expression, localization, and molecular interactions. They enable techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding in the exploration of Menin's tumor-suppressive mechanisms and its role in chromatin remodeling. Recent studies highlight Menin's involvement in blocking oncogenic pathways, particularly in mixed-lineage leukemia (MLL)-rearranged leukemias, where Menin-MLL inhibitors are under clinical investigation. The antibody's utility extends to validating experimental models and assessing therapeutic targeting efficiency. As Menin gains attention as a potential therapeutic target, its antibody remains essential for both basic research and drug development, bridging molecular insights with clinical applications.
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