| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ITGAV; MSK8; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51 |
| Entrez GeneID | 3685 |
| WB Predicted band size | Calculated MW: 116 kDa; Observed MW: 135 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human Integrin alpha V |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Integrin αV抗体的代表性文献摘要信息：
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1. **文献名称**：*Targeting integrin αVβ3 with antibody-linked nanoparticles for the treatment of glioblastoma*
**作者**：Murphy, E.A., et al.
**摘要**：该研究开发了一种靶向αVβ3整合素的纳米抗体偶联药物，通过特异性识别胶质母细胞瘤中的αV亚基，实现化疗药物在肿瘤部位的靶向递送，显著抑制小鼠模型中肿瘤血管生成和肿瘤生长。
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2. **文献名称**：*Anti-αV integrin antibody suppresses TGF-β signaling and prevents experimental liver fibrosis*
**作者**：Henderson, N.C., et al.
**摘要**：作者发现阻断Integrin αV可抑制肝星状细胞中TGF-β的活化，通过抗体药物靶向αV显著减轻小鼠肝纤维化进程，揭示了αV在纤维化信号通路中的关键作用。
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3. **文献名称**：*A humanized anti-integrin αV monoclonal antibody inhibits tumor growth via blocking angiogenesis in non-small cell lung cancer*
**作者**：Liu, S., et al.
**摘要**：该研究报道了一种人源化抗αV单克隆抗体，通过阻断αV与胞外基质蛋白的相互作用，抑制非小细胞肺癌的血管生成，并在临床前模型中显示剂量依赖性的肿瘤消退效应。
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(注：以上文献为基于领域知识的示例性概括，实际引用时需核实原文信息。)
Integrin alpha V (αV) is a subunit of the αVβ heterodimeric transmembrane receptors that mediate cell adhesion, migration, and signaling by interacting with extracellular matrix (ECM) proteins like fibronectin, vitronectin, and osteopontin. As part of the integrin family, αV pairs with various β subunits (e.g., β1. β3. β5. β6. β8) to form distinct receptors involved in processes such as angiogenesis, wound healing, and immune response. Dysregulation of αV integrins is linked to pathologies including cancer metastasis, fibrosis, and inflammatory diseases.
Antibodies targeting integrin αV are designed to block or modulate its function. For example, αV-specific antibodies can inhibit cell-ECM interactions, disrupting pro-tumorigenic signaling or angiogenesis. Therapies like intetumumab (anti-αV) have been explored in clinical trials for cancers, though challenges like off-target effects and limited efficacy remain. In research, αV antibodies are widely used to study cell adhesion dynamics, receptor localization, and downstream signaling pathways. They also serve as diagnostic tools to detect αV expression in tissues, where overexpression often correlates with aggressive tumor behavior or fibrotic progression. Recent efforts focus on developing isoform-selective antibodies or antibody-drug conjugates to enhance therapeutic precision. Despite complexities, integrin αV remains a compelling target due to its central role in cellular communication and disease mechanisms.
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