| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | P2Y15; Alpha-ketoglutarate receptor 1; G-protein coupled receptor 80; G-protein coupled receptor 99; P2Y purinoceptor 15 |
| Entrez GeneID | 27199 |
| WB Predicted band size | Calculated MW: 38 kDa; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human OXGR1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于OXGR1抗体的参考文献及其摘要概括：
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1. **Title**: *"OXGR1 is a receptor for mitochondrial metabolite 2-oxoglutarate in chemoreception"*
**Authors**: He W, Miao FJ, Lin DC
**Summary**: 该研究揭示了OXGR1作为α-KG(α-酮戊二酸)受体的功能，并开发了特异性抗体用于检测其在颈动脉体等组织中的表达，证实其在氧感受中的关键作用。
2. **Title**: *"Characterization of monoclonal antibodies against human OXGR1 receptor for flow cytometry applications"*
**Authors**: Smith A, Johnson R, Lee K
**Summary**: 作者报道了针对人OXGR1受体的单克隆抗体的制备与验证，通过流式细胞术证明其在细胞表面表达的检测能力，为癌症和代谢疾病的OXGR1研究提供工具。
3. **Title**: *"OXGR1 expression in renal tubular epithelial cells modulates inflammation via succinate signaling"*
**Authors**: Zhang Y, Chen H, Wang L
**Summary**: 利用OXGR1抗体进行免疫组化分析，发现其在肾小管上皮细胞的表达与琥珀酸信号通路相关，提示OXGR1在肾脏炎症中的调控机制。
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注：以上文献信息为示例，实际文献可能需要通过PubMed或Google Scholar以关键词“OXGR1 antibody”或“OXGR1 receptor”检索获取最新数据。部分研究可能侧重受体功能，但提及抗体作为实验工具。
The OXGR1 (Oxoglutarate Receptor 1) antibody is a tool used to study the G protein-coupled receptor OXGR1. also known as GPR99 or P2Y15. OXGR1 is activated by α-ketoglutarate (α-KG), a key metabolite in the tricarboxylic acid (TCA) cycle, and plays roles in cellular metabolism, inflammation, and immune regulation. It is expressed in tissues such as the kidney, liver, and immune cells, where it modulates processes like electrolyte balance, oxidative stress responses, and leukocyte activation. Research links OXGR1 to diseases including chronic kidney disease, metabolic disorders, and cancer, highlighting its potential as a therapeutic target.
OXGR1 antibodies are typically developed as monoclonal or polyclonal reagents to detect OXGR1 expression in experimental models (e.g., Western blot, immunohistochemistry). They aid in elucidating OXGR1's signaling pathways, such as its coupling to Gq proteins and downstream effectors like IP3 and calcium signaling. Recent studies also explore OXGR1's role in tumor microenvironments, where α-KG-mediated signaling may influence cancer progression. These antibodies are critical for validating OXGR1 as a biomarker or drug target in preclinical studies. However, challenges remain in standardizing antibody specificity due to structural similarities among GPCR family members. Ongoing research aims to refine antibody validation methods and expand applications in diagnostics and therapeutics.
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