| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TNF alpha-induced protein 8; NDED; SCC-S2 |
| Entrez GeneID | 25816 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 21-23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human TNFAIP8 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于TNFAIP8抗体的参考文献示例(文献信息为模拟虚构，仅供参考)：
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1. **文献名称**：*TNFAIP8-specific antibody inhibits tumor growth by promoting apoptosis in colorectal cancer*
**作者**：Li Y, et al.
**摘要**：研究开发了一种高特异性TNFAIP8单克隆抗体，发现其通过阻断TNFAIP8与PI3K/Akt通路相互作用，诱导结直肠癌细胞凋亡并抑制小鼠移植瘤生长。
2. **文献名称**：*TNFAIP8 antibody-based detection reveals its overexpression as a prognostic biomarker in hepatocellular carcinoma*
**作者**：Wang H, et al.
**摘要**：利用TNFAIP8多克隆抗体对肝癌组织进行免疫组化分析，发现TNFAIP8高表达与患者生存率降低显著相关，提示其可作为肝癌预后标志物。
3. **文献名称**：*TNFAIP8 regulates macrophage polarization via antibody-targeted inhibition in sepsis models*
**作者**：Chen J, et al.
**摘要**：通过抗TNFAIP8抗体干预脓毒症小鼠模型，发现TNFAIP8通过调控NF-κB信号通路影响巨噬细胞向M1型极化，抗体治疗显著减轻全身炎症反应。
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注：以上文献为示例，实际研究中请通过PubMed、Web of Science等数据库检索真实发表的论文。
**Background of TNFAIP8 Antibody**
TNFAIP8 (Tumor Necrosis Factor Alpha-Induced Protein 8), also known as SCC-S2 or NDED, is a member of the TNFAIP8 family, which plays roles in apoptosis, immunity, and cancer progression. TNFAIP8 was initially identified as a gene induced by the transcription factor NF-κB in response to TNF-α signaling. It is characterized by a conserved death effector domain (DED)-like structure, enabling interactions with signaling molecules involved in cell survival and inflammation.
TNFAIP8 antibodies are essential tools for studying the protein’s expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect TNFAIP8 in various biological samples, including cancer tissues, immune cells, and cultured cell lines. Research highlights TNFAIP8’s dual role in promoting cell survival and suppressing apoptosis, particularly in cancer contexts. Overexpression of TNFAIP8 correlates with tumor growth, metastasis, and poor prognosis in cancers such as breast, lung, and hepatocellular carcinoma. Additionally, TNFAIP8 regulates immune responses by modulating TLR (Toll-like receptor) signaling and cytokine production, linking it to inflammatory and autoimmune diseases.
Antibodies targeting TNFAIP8 help elucidate its mechanisms in disease pathogenesis, serving as potential biomarkers or therapeutic targets. Validated antibodies ensure specificity through knockdown/knockout controls, supporting their reliability in both basic and translational research. Commercial TNFAIP8 antibodies are typically raised in hosts like rabbits or mice, with options for monoclonal or polyclonal formats.
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