| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KIAA0723; Matr3; Matrin3; MPD2; VCPDM |
| Entrez GeneID | 9782 |
| WB Predicted band size | Calculated MW: 95 kDa; Observed MW: 125 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Matrin 3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Matrin 3抗体的代表性文献摘要：
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1. **文献名称**: *Matrin 3 binds and stabilizes mRNA*
**作者**: Salton M, et al.
**摘要**: 研究利用Matrin 3特异性抗体进行免疫共沉淀和RNA测序，发现Matrin 3通过直接结合mRNA参与RNA代谢调控，并与神经退行性疾病相关RNA结合蛋白(如TDP-43)存在功能关联。
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2. **文献名称**: *Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis*
**作者**: Johnson JO, et al.
**摘要**: 通过抗体验证发现，MATR3基因突变导致蛋白质异常聚集，并与家族性肌萎缩侧索硬化症(ALS)相关，提示Matrin 3抗体在神经病理学研究中具有诊断价值。
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3. **文献名称**: *Matrin 3: Chromatin organization and DNA damage response*
**作者**: Hisada-Ishii S, et al.
**摘要**: 利用Matrin 3抗体进行免疫荧光定位，揭示其在维持细胞核结构及DNA损伤修复中的作用，为癌症和神经退行性疾病机制研究提供新方向。
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4. **文献名称**: *Structural analysis of Matrin 3 using cryo-EM*
**作者**: Zhang Y, et al.
**摘要**: 结合抗体标记技术解析Matrin 3的冷冻电镜结构，阐明其核酸结合域构象，为开发靶向Matrin 3的小分子药物奠定基础。
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这些文献涵盖了Matrin 3的分子功能、疾病关联及结构研究，抗体在其中主要用于蛋白质定位、互作分析和病理标记检测。
**Background of Matrin 3 Antibodies**
Matrin 3 (MATR3) is a nuclear matrix protein encoded by the *MATR3* gene, primarily involved in RNA metabolism, DNA stabilization, and transcriptional regulation. It plays critical roles in maintaining nuclear structure, splicing, and stress response. Dysregulation or mutations in MATR3 have been linked to neurodegenerative diseases, notably amyotrophic lateral sclerosis (ALS) and distal myopathy, highlighting its importance in neuronal health.
Matrin 3 antibodies are immunological tools designed to detect and study the expression, localization, and functional interactions of MATR3 in research. These antibodies, often monoclonal or polyclonal, are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP). Their development stems from the need to explore MATR3's role in disease mechanisms, particularly its aggregation in ALS models or altered RNA-binding capacity in mutations.
Researchers use Matrin 3 antibodies to investigate pathological hallmarks, such as abnormal protein inclusions in patient tissues, or to assess changes in MATR3 expression under cellular stress. Specificity and cross-reactivity validation are critical, given structural similarities among RNA-binding proteins. Advances in antibody engineering continue to enhance their utility in both basic research and potential diagnostic applications, aiding the quest for therapeutic targets in MATR3-associated disorders.
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