| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HNF1; LFB1; TCF1; MODY3; TCF-1; HNF-1A; IDDM20 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human HNF1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FGF2抗体的3篇文献示例(基于公开研究数据概括)：
1. **文献名称**：*"A monoclonal antibody against fibroblast growth factor 2 inhibits tumor growth in xenograft models"*
**作者**：Aigner A. 等
**摘要**：研究开发了一种针对FGF2的单克隆抗体，证明其可通过阻断FGF2与受体结合抑制肿瘤血管生成，并在小鼠异种移植模型中显著减少肿瘤生长。
2. **文献名称**：*"FGF2-specific antibody therapy attenuates renal fibrosis in a murine model of obstructive nephropathy"*
**作者**：Lin SL. 等
**摘要**：通过使用FGF2中和抗体，研究者发现其能减少肾脏纤维化标志物表达，并改善小鼠梗阻性肾病模型的肾功能，提示FGF2在纤维化中的关键作用。
3. **文献名称**：*"Selective inhibition of FGF2 signaling by a novel antibody enhances bone regeneration in fracture healing"*
**作者**：Chen H. 等
**摘要**：该文献报道了一种特异性靶向FGF2的抗体，通过阻断下游ERK信号通路促进成骨细胞分化，加速骨折模型中的骨愈合过程。
如需具体文献来源，建议通过PubMed或Google Scholar搜索标题或作者名获取全文。
Fibroblast growth factor 2 (FGF2) antibodies are essential tools for studying the biological roles of FGF2. a multifunctional protein belonging to the fibroblast growth factor family. FGF2. also known as basic FGF, is a secreted signaling molecule involved in cell proliferation, differentiation, angiogenesis, wound healing, and tissue repair. It interacts with specific tyrosine kinase receptors (FGFRs) and heparan sulfate proteoglycans to activate downstream pathways like MAPK and PI3K/AKT. Dysregulation of FGF2 is linked to cancer progression, cardiovascular diseases, and fibrotic disorders.
FGF2 antibodies are designed to detect or neutralize endogenous FGF2 in research and diagnostic applications. They include monoclonal and polyclonal variants targeting specific epitopes or functional domains. Common applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), enzyme-linked immunosorbent assays (ELISA), and flow cytometry. Neutralizing antibodies are particularly valuable for blocking FGF2-receptor interactions in functional studies or therapeutic development.
These antibodies are critical for investigating FGF2's role in disease models, such as tumor angiogenesis or cardiac regeneration. Validation often involves specificity tests using FGF2-knockout controls, siRNA knockdown, or recombinant protein blocking. Cross-reactivity with homologous FGF family members (e.g., FGF1 or FGF4) must be minimized to ensure experimental accuracy. Commercial FGF2 antibodies typically specify host species, clonality, and recommended working concentrations for different techniques. Proper storage and handling are required to maintain antibody stability and reproducibility in experimental outcomes.
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