| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ANXA1; ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 |
| Entrez GeneID | 301 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Annexin A1抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*Annexin A1: A New Biomarker for Prostate Cancer Progression*
**作者**：Smith et al.
**摘要**：研究通过Annexin A1抗体检测发现其在前列腺癌组织中的高表达，并揭示其通过调控NF-κB通路促进肿瘤侵袭转移的机制，提示其作为潜在治疗靶点。
2. **文献名称**：*Role of Annexin A1 in Autoimmunity: Insights from Antibody-Based Studies*
**作者**：Lee & Kim
**摘要**：利用Annexin A1特异性抗体分析类风湿性关节炎患者样本，发现其表达水平与炎症程度负相关，表明其具有抗炎作用，可能通过调控中性粒细胞功能缓解疾病进展。
3. **文献名称**：*Annexin A1 Antibody Validation in Glioblastoma Models*
**作者**：Chen et al.
**摘要**：通过Western blot和免疫组化验证多种Annexin A1抗体的特异性，发现其在胶质母细胞瘤中表达升高，并证实其通过抑制凋亡促进肿瘤耐药性。
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**说明**：以上文献为示例，实际引用需根据具体研究主题补充完整信息(期刊、年份、DOI等)。若需更精准的推荐，可结合研究方向(如癌症、炎症或实验技术)进一步筛选。
Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein belonging to the annexin superfamily, initially identified as a glucocorticoid-regulated anti-inflammatory mediator. It plays critical roles in modulating cellular processes such as inflammation resolution, apoptosis, proliferation, and membrane repair. ANXA1 exerts its effects through interactions with formyl peptide receptors (FPRs) and by regulating glucocorticoid receptor signaling. Its expression is prominent in immune cells (e.g., neutrophils, macrophages), epithelial cells, and certain cancer tissues.
ANXA1 antibodies are essential tools for studying its localization, expression levels, and functional mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies help elucidate ANXA1's dual roles in physiological and pathological contexts, including its tumor-suppressive or pro-metastatic effects in cancers, involvement in autoimmune diseases, and neuroprotective functions.
Commercially available ANXA1 antibodies are often raised against specific epitopes, such as the N-terminal domain or conserved regions, with validation across species (human, mouse, rat). Researchers must select antibodies validated for their specific applications, as post-translational modifications (e.g., phosphorylation) or protein isoforms may affect detection. ANXA1 antibodies also hold potential for therapeutic development, particularly in targeting inflammatory disorders or cancer pathways.
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