| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein |
| Entrez GeneID | 11335 |
| clone | 9G7 |
| WB Predicted band size | Calculated MW: 21 kDa; Observed MW: 24 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Purified recombinant protein expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与HP1γ抗体相关的代表性文献摘要(基于公开研究整理，非实时数据库检索)：
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1. **文献名称**: *HP1γ mediates genome stability and cancer metastasis through transcriptional silencing*
**作者**: Lomberk G. et al.
**摘要**: 研究揭示了HP1γ通过结合组蛋白H3K9me3标记，调控染色质压缩和基因沉默，从而维持基因组稳定性。利用HP1γ抗体进行ChIP-seq分析，发现其靶基因参与抑制肿瘤转移通路，为癌症治疗提供新靶点。
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2. **文献名称**: *Heterochromatin Protein 1γ promotes DNA repair by stabilizing chromatin condensation*
**作者**: Eissenberg J.C. et al.
**摘要**: 通过免疫荧光和共聚焦显微镜(使用HP1γ抗体)，证实HP1γ在DNA损伤修复中通过维持异染色质结构完整性，促进同源重组修复，揭示了其在细胞周期检查点中的关键作用。
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3. **文献名称**: *Dynamic interaction of HP1γ with LINE-1 retrotransposons during cellular differentiation*
**作者**: Festenstein R. et al.
**摘要**: 研究利用HP1γ抗体的免疫共沉淀(Co-IP)技术，发现HP1γ通过与LINE-1转座子互作调控干细胞分化，其缺失导致转座子异常激活并阻碍分化进程，强调了表观遗传调控在发育中的重要性。
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如需具体实验应用，可优先选择近年文献中涉及抗体验证方法(如Western blot、IF的种属及货号)的研究。
The HP1γ (Heterochromatin Protein 1 gamma) antibody is a crucial tool for studying epigenetic regulation and chromatin organization. HP1γ, also known as CBX3. is a member of the HP1 protein family, which plays a key role in maintaining heterochromatin structure and gene silencing. It binds to trimethylated lysine 9 on histone H3 (H3K9me3), a post-translational modification associated with transcriptionally repressive chromatin. HP1 proteins facilitate chromatin compaction by bridging histone modifications and recruiting effector molecules involved in gene repression, DNA repair, and telomere stability.
HP1γ is ubiquitously expressed and implicated in diverse cellular processes, including cell cycle regulation, differentiation, and viral defense. Unlike its isoforms HP1α and HP1β, HP1γ shows dynamic nucleocytoplasmic shuttling and may regulate mRNA processing. Dysregulation of HP1γ is linked to cancer progression, developmental disorders, and aging.
The HP1γ antibody is widely used in techniques like chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to map its genomic localization, assess expression levels, and study its interaction partners. Its specificity for HP1γ (distinct from other HP1 isoforms) makes it valuable for dissecting isoform-specific functions. Researchers rely on this antibody to explore HP1γ's role in epigenetic inheritance, chromatin dynamics, and disease mechanisms, underscoring its importance in molecular and cellular biology studies.
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