| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type ii cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7 |
| Entrez GeneID | 3855 |
| clone | 9G9 |
| WB Predicted band size | Calculated MW: 51 kDa; Observed MW: 54 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of CK7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是3-4条关于Cytokeratin 7(CK7)抗体的参考文献及其摘要概括：
---
1. **文献名称**: *Cytokeratin 7 and Cytokeratin 20 in Primary and Secondary Cutaneous Adnexal Neoplasms*
**作者**: Ramdial PK, et al.
**摘要**: 研究探讨CK7和CK20在皮肤附件肿瘤中的表达差异，发现CK7在汗腺源性肿瘤中高表达，而CK20在毛囊/皮脂腺肿瘤中罕见，提示CK7抗体可用于鉴别诊断附件肿瘤来源。
2. **文献名称**: *Utility of Cytokeratin 7 and 20 in the Differential Diagnosis of Metastatic Carcinoma*
**作者**: Tot T.
**摘要**: 分析CK7/CK20免疫组化组合在转移癌鉴别中的价值，指出CK7阳性/CK20阴性模式常见于肺、乳腺及卵巢癌，有助于确定原发灶位置。
3. **文献名称**: *Cytokeratin 7 Immunoreactivity in Renal Cell Carcinoma*
**作者**: Langner C, et al.
**摘要**: 评估CK7在肾细胞癌中的表达，发现其在不同亚型中表达差异显著(如嫌色细胞癌高表达)，支持CK7抗体在肾肿瘤分型中的应用。
4. **文献名称**: *Cytokeratin 7 and 19 as Prognostic Markers in Urothelial Carcinoma*
**作者**: Retz M, et al.
**摘要**: 研究CK7和CK19在膀胱尿路上皮癌中的表达与预后的关系，发现CK7高表达与肿瘤侵袭性相关，可能作为疾病进展的生物标志物。
---
以上文献覆盖了CK7抗体在肿瘤分型、转移灶鉴别及预后评估中的关键应用。如需全文链接或具体期刊信息，可进一步提供。
Cytokeratin 7 (CK7) is a member of the cytokeratin family, a group of intermediate filament proteins critical for maintaining epithelial cell structure and integrity. Expressed in various simple, glandular, and transitional epithelia, CK7 is commonly found in tissues such as the lung, breast, thyroid, and urogenital tract. Its antibody is widely utilized in diagnostic pathology to identify epithelial cell origins, particularly in cancer classification.
As a type II acidic keratin (paired with CK19), CK7 helps distinguish between adenocarcinomas of different primary sites. For example, CK7+/CK20− profiles often indicate lung or ovarian cancers, while CK7−/CK20+ patterns suggest colorectal origins. It also aids in differentiating carcinomas from mesotheliomas or sarcomas.
In research, CK7 antibodies are essential for studying epithelial differentiation, metastasis, and tissue regeneration. Immunohistochemistry (IHC) remains the primary method for detecting CK7 expression, though challenges like cross-reactivity or variable staining intensity require careful validation. Despite limitations, CK7 remains a cornerstone biomarker in tumor diagnostics, reflecting its reliability in tracing epithelial lineage and guiding clinical decision-making.
×
