| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | La; LARP3; La/SSB |
| Entrez GeneID | 6741 |
| clone | 7A5 |
| WB Predicted band size | Calculated MW: 47 kDa; Observed MW: 50 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant human La Antigen protein fragments expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于SSB抗体的3篇代表性文献信息(基于公开研究整理，非实时数据库检索)：
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1. **文献名称**：*Autoantibodies against SSB/La: Clinical significance and association with SSA/Ro antibodies*
**作者**：Reichlin M, et al.
**摘要**：探讨SSB抗体在系统性红斑狼疮(SLE)和干燥综合征中的临床意义，发现其常与SSA抗体共存，且与唾液腺损伤、肾炎等特定临床表现相关。
2. **文献名称**：*The SSB/La autoantigen in systemic autoimmune diseases: Epitope mapping and functional insights*
**作者**：Routsias JG, Tzioufas AG.
**摘要**：通过表位定位分析SSB抗体的抗原结合区域，揭示其与RNA结合功能的关联，并讨论其在自身免疫疾病中触发炎症反应的潜在机制。
3. **文献名称**：*SSB/La antibodies in neonatal lupus: A marker of cardiac risk?*
**作者**：Buyon JP, et al.
**摘要**：研究SSB抗体与SSA抗体共同阳性孕妇的胎儿心脏传导阻滞风险，提示SSB抗体可能协同SSA抗体增加新生儿狼疮的心脏并发症概率。
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**备注**：如需准确引用，建议通过PubMed或Google Scholar检索上述标题验证详细信息，或补充关键词获取更新文献。
**Background of SSB Antibodies**
SSB antibodies, also known as anti-La antibodies, are autoantibodies targeting the SSB (Sjögren’s syndrome type B) antigen, a 48-kDa phosphoprotein associated with RNA polymerase III-transcribed RNAs. This antigen plays a role in RNA processing and quality control, particularly in the stabilization of small RNA molecules like tRNA precursors. SSB antibodies are clinically significant in autoimmune disorders, most notably Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE).
These antibodies are detected in approximately 30-60% of primary SS patients, often coexisting with anti-SSA/Ro antibodies. Their presence is associated with more severe exocrine gland dysfunction, including xerostomia and keratoconjunctivitis sicca. In SLE, SSB antibodies are less common (10-15% of cases) and may correlate with specific manifestations like cutaneous involvement or neonatal lupus, particularly congenital heart block in offspring of antibody-positive mothers.
Diagnostically, SSB antibodies are part of the serological criteria for SS and aid in differentiating primary from secondary SS. Their detection, typically via ELISA or immunoblot, complements clinical evaluation. While their exact pathogenic role remains unclear, SSB antibodies are thought to arise from immune dysregulation triggered by viral infections (e.g., Epstein-Barr virus) or genetic factors (e.g., HLA-DR3 haplotype). Research continues to explore their molecular mechanisms and prognostic implications in autoimmune diseases.
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