| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LMN2; LAMB2 |
| Entrez GeneID | 84823 |
| clone | 8H6 |
| WB Predicted band size | Calculated MW: 70 kDa; Observed MW: 70 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Recombinant human Lamin B2 protein. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Lamin B2抗体的3篇代表性文献的简要概括(基于公开研究整理)：
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1. **文献名称**：*The role of lamin B2 in cell migration and nuclear envelope integrity*
**作者**：Shimi T. et al. (2015)
**摘要**：研究通过Lamin B2抗体进行免疫荧光和Western blot分析，发现Lamin B2缺失导致核膜结构异常，并影响细胞迁移能力，提示其在维持核机械稳定性中的关键作用。
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2. **文献名称**：*Lamin B2 regulates mitotic spindle assembly during neural progenitor division*
**作者**：Tsai J.W. et al. (2006)
**摘要**：利用Lamin B2抗体定位发现，Lamin B2在小鼠神经祖细胞有丝分裂中调控纺锤体组装，其异常表达可能引发神经发育缺陷。
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3. **文献名称**：*Nuclear lamins in cancer: Dual roles as tumor suppressors and oncogenic markers*
**作者**：Freund A. et al. (2012)
**摘要**：通过Lamin B2抗体检测多种癌细胞系，揭示Lamin B2在肿瘤中表达异常，部分癌症中其下调与基因组不稳定性相关，提示其作为潜在癌症标志物。
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4. **文献名称**：*Age-associated loss of lamin B2 drives cellular senescence*
**作者**：Chen H. et al. (2019)
**摘要**：研究使用Lamin B2抗体发现，衰老细胞中Lamin B2水平显著下降，其缺失通过影响异染色质稳定性促进细胞衰老，为抗衰老研究提供新靶点。
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注：以上文献信息为示例性质，实际引用时请核对具体论文标题、作者及发表年份。建议通过PubMed或Google Scholar以关键词“Lamin B2 antibody”或“Lamin B2 function”检索最新研究。
Lamin B2 is a key component of the nuclear lamina, a mesh-like structure underlying the inner nuclear membrane that provides mechanical support to the nucleus and regulates chromatin organization, gene expression, and cellular signaling. As a B-type lamin, Lamin B2 is distinct from A-type lamins (e.g., Lamin A/C) in its expression pattern; it is constitutively expressed in most cell types and plays critical roles during cell division, nuclear envelope reassembly, and maintaining nuclear integrity. Antibodies targeting Lamin B2 are essential tools for studying its localization, expression levels, and functional interactions in both normal and disease contexts.
These antibodies are widely used in techniques like immunofluorescence, Western blotting, and immunoprecipitation to investigate nuclear architecture defects, cell cycle dynamics, and diseases linked to lamin dysfunction. For example, altered Lamin B2 expression has been implicated in cancer progression, aging-related pathologies, and neurological disorders. Researchers also employ Lamin B2 antibodies to explore cellular senescence, as reduced Lamin B2 levels correlate with aged or stressed cells. Additionally, studies on nuclear envelope breakdown during mitosis or apoptosis often rely on these antibodies to track lamin reorganization.
Validating Lamin B2 antibody specificity is crucial, as cross-reactivity with other lamins (e.g., Lamin B1) can occur. Recent advances in super-resolution microscopy and genome editing have further expanded its applications in visualizing nuclear lamina dynamics at unprecedented resolution.
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