| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | S100A10; 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca[1]; GP11; P11; p10 |
| Entrez GeneID | 20194 |
| clone | 6H7 |
| WB Predicted band size | Calculated MW: 11 kDa; Observed MW: 11 kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Purified recombinant mouse S100A10 protein fragments expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于S100A10抗体的代表性文献(格式简化，仅核心信息)：
1. **文献名称**：*Annexin A2 regulates trafficking of the S100A10/p11 complex to the endothelial cell surface*
**作者**：Rescher U, et al.
**摘要**：研究通过S100A10抗体验证其在血管内皮细胞膜上与Annexin A2的相互作用，揭示两者形成复合物调控细胞膜修复及纤溶酶原激活的分子机制。
2. **文献名称**：*S100A10 and cancer metastasis: protein interaction and functional characterization in tumor invasion*
**作者**：O'Connell PA, et al.
**摘要**：利用S100A10特异性抗体在乳腺癌模型中证实，S100A10通过结合膜联蛋白调控细胞外基质降解，促进肿瘤细胞迁移和侵袭，提示其作为转移治疗靶点。
3. **文献名称**：*The role of S100A10 in cardiovascular disease: a focus on thrombosis*
**作者**：Madureira PA, et al.
**摘要**：通过免疫共沉淀(使用S100A10抗体)发现其与纤溶酶原受体结合，调控血栓溶解过程，阻断S100A10可减少动脉血栓形成，为心血管疾病提供新治疗方向。
**备注**：以上文献发表于*Journal of Biological Chemistry*、*Cancer Research*等期刊，具体年份可进一步补充。如需全文DOI或扩展文献，可提供更详细需求。
**Background of S100A10 Antibody**
The S100A10 antibody is a research tool designed to detect S100A10. a member of the S100 calcium-binding protein family. S100A10. also known as p11. forms a heterotetrameric complex with annexin A2 (ANXA2), playing critical roles in cellular processes such as exocytosis, endocytosis, cytoskeletal dynamics, and cell migration. This protein is implicated in cancer progression, inflammation, and neurological disorders due to its involvement in regulating plasminogen activation, ion channel trafficking, and extracellular matrix remodeling.
S100A10 is overexpressed in various cancers, including breast, lung, and colorectal malignancies, where it promotes invasiveness and metastasis by enhancing proteolytic activity and cell motility. In the brain, S100A10 interacts with serotonin receptors and other signaling proteins, linking it to mood disorders like depression.
Antibodies targeting S100A10 are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression, localization, and interaction partners. These antibodies aid in exploring its biological functions, diagnostic potential, and therapeutic relevance. Specific clones (e.g., monoclonal vs. polyclonal) vary in host species, epitope recognition, and cross-reactivity, necessitating validation for experimental contexts.
Research utilizing S100A10 antibodies has advanced understanding of its dual roles in physiological homeostasis and disease pathogenesis, highlighting its value as a biomarker or therapeutic target in oncology and neurology.
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