| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prealbumin; TBPA; Amyloidosis I; Transthyretin |
| Entrez GeneID | 7276 |
| clone | 2H8 |
| WB Predicted band size | Calculated MW: 16 kDa; Observed MW: 16 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant protein expressed in E.coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于前白蛋白(Transthyretin/Prealbumin)抗体的参考文献及摘要概括：
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1. **文献名称**: *Monoclonal Antibodies against Human Transthyretin: Epitope Mapping and Application in Immunoassays*
**作者**: Saraiva, M.J. et al.
**摘要**: 该研究开发了针对人转甲状腺素蛋白(前白蛋白)的单克隆抗体，通过表位定位确定了抗体结合区域，并验证了其在ELISA检测中的高特异性，为临床诊断提供了新工具。
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2. **文献名称**: *Autoantibodies to Transthyretin in Familial Amyloidotic Polyneuropathy*
**作者**: Sousa, M.M. et al.
**摘要**: 研究揭示了家族性淀粉样多发性神经病变(FAP)患者体内存在针对突变型前白蛋白的自身抗体，提示抗体可能参与疾病病理过程或具有潜在生物标志物价值。
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3. **文献名称**: *Structural Insights into Transthyretin-Antibody Interactions Using Cryo-EM*
**作者**: Hörnberg, A. et al.
**摘要**: 通过冷冻电镜技术解析了前白蛋白与其特异性抗体结合的复合物结构，阐明了抗体识别前白蛋白淀粉样纤维的分子机制，为靶向治疗策略提供结构基础。
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注：以上文献信息为模拟示例，实际文献需通过PubMed或专业数据库检索确认。
**Background of Prealbumin (Transthyretin) Antibodies**
Prealbumin, also known as transthyretin (TTR), is a 55-kDa tetrameric protein primarily synthesized in the liver and choroid plexus. It functions as a carrier for thyroid hormones (T3/T4) and retinol-binding protein (RBP)-bound vitamin A. Due to its short half-life (~2 days) and rapid turnover, prealbumin is a sensitive biomarker for assessing nutritional status and monitoring acute-phase responses in clinical settings.
Antibodies targeting prealbumin are essential tools in research and diagnostics. They enable the detection and quantification of prealbumin in biological samples via techniques like ELISA, Western blot, and immunohistochemistry. These antibodies are particularly valuable in studying TTR-related amyloidosis, a group of disorders caused by the misfolding and aggregation of mutant or wild-type TTR into amyloid fibrils, leading to organ dysfunction. For example, hereditary transthyretin amyloidosis (ATTRv) is linked to TTR gene mutations, while wild-type ATTR amyloidosis is age-associated.
Commercially available prealbumin antibodies include monoclonal and polyclonal variants. Monoclonal antibodies offer high specificity by recognizing a single epitope, whereas polyclonal antibodies detect multiple epitopes, enhancing sensitivity. Validation parameters, such as cross-reactivity and application-specific performance, are critical for ensuring reliability.
In clinical diagnostics, prealbumin antibodies aid in differentiating amyloid subtypes and assessing nutritional interventions. Research applications focus on elucidating TTR’s role in disease mechanisms and evaluating therapeutic strategies, such as TTR stabilizers or gene-silencing therapies. Proper antibody selection and experimental optimization remain pivotal for accurate data interpretation.
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