| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STMN1; C1orf215; LAP18; OP18; Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17 |
| Entrez GeneID | 3925 |
| WB Predicted band size | Calculated MW: 17 kDa; Observed MW: 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human STMN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是3篇与Phospho-Stathmin 1 (Ser25)抗体相关的文献概览：
---
1. **文献名称**: *Stathmin phosphorylation by p38 MAPK regulates microtubule dynamics in mitotic cells*
**作者**: Marklund, U. et al.
**摘要**: 研究揭示了p38 MAPK通过磷酸化Stathmin1的Ser25位点调控微管稳定性，影响有丝分裂纺锤体形成，抗体用于检测磷酸化水平与细胞周期进程的关联。
---
2. **文献名称**: *Phosphorylation of stathmin at Ser25 promotes cancer progression via ERK signaling*
**作者**: Li, Y. et al.
**摘要**: 在乳腺癌模型中，利用Phospho-Ser25抗体证实该位点磷酸化通过激活ERK通路促进肿瘤侵袭和转移，提示其作为潜在治疗靶点。
---
3. **文献名称**: *Differential phosphorylation of stathmin during neuronal differentiation*
**作者**: Gavet, O. et al.
**摘要**: 通过免疫印迹和免疫荧光(使用Ser25特异性抗体)，发现神经元分化过程中Stathmin1的Ser25磷酸化动态变化与微管重组及轴突生长相关。
---
注：以上为虚构示例，实际文献需通过PubMed/Google Scholar检索关键词“Phospho-Stathmin 1 Ser25”或相关研究领域筛选。
Phospho-Stathmin 1 (Ser25) antibody is a specialized tool used to detect the phosphorylation of Stathmin 1 at serine residue 25. a post-translational modification critical for regulating its activity. Stathmin 1. also known as oncoprotein 18 (OP18), is a cytosolic phosphoprotein involved in microtubule dynamics by promoting depolymerization or preventing polymerization of tubulin heterodimers. Its function is tightly regulated by phosphorylation, particularly during cell cycle progression, differentiation, and stress responses. Phosphorylation at Ser25. along with other residues (e.g., Ser16. Ser38. and Ser63), modulates Stathmin 1’s microtubule-destabilizing activity, influencing mitotic spindle formation and cell division.
The Ser25 phosphorylation site is primarily targeted by cyclin-dependent kinases (CDKs) and mitogen-activated protein kinases (MAPKs), linking its activity to cell cycle checkpoints (e.g., G2/M transition) and signaling pathways responsive to extracellular stimuli. Dysregulation of Stathmin 1 phosphorylation is associated with cancer progression, neurodegenerative disorders, and developmental defects, as abnormal microtubule dynamics can impair mitotic fidelity, intracellular transport, or neuronal morphogenesis.
Phospho-Stathmin 1 (Ser25) antibodies enable researchers to study the spatiotemporal activation of Stathmin 1 in various contexts, such as drug-induced mitotic arrest, neuronal development, or cancer cell migration. These antibodies are validated for techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the exploration of Stathmin 1’s role in health and disease. Specificity for the phosphorylated Ser25 epitope ensures accurate detection of the active regulatory state, making it essential for mechanistic studies of microtubule-related processes.
×
