WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/50-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/10000 | Human,Mouse,Rat |
Aliases | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
Entrez GeneID | 1956 |
WB Predicted band size | Calculated MW: 134 kDa; Observed MW: 140-160 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Tyr1092. AA range:1061-1110 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Phospho-EGFR (Tyr1092)抗体的3篇参考文献示例,包含文献名称、作者及摘要概括:
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1. **文献名称**:*Distinct phosphorylation sites on EGFR differentially regulate downstream signaling pathways*
**作者**:Sordella, R., Bell, D.W., Haber, D.A.
**摘要**:研究分析了EGFR不同酪氨酸磷酸化位点(包括Tyr1092)的功能差异,发现Tyr1092的磷酸化在激活MAPK通路和促进细胞增殖中起关键作用,与肿瘤生长相关。
2. **文献名称**:*Dynamic profiling of EGFR phosphorylation reveals site-specific signaling networks*
**作者**:Huang, F., Grecco, H.E., Cohen, S.
**摘要**:通过质谱和抗体检测,系统研究了EGF刺激后EGFR多个磷酸化位点(含Tyr1092)的动态变化,揭示Tyr1092在招募适配蛋白Grb2和启动下游信号中的重要性。
3. **文献名称**:*Phospho-EGFR (Tyr1092) as a prognostic biomarker in glioblastoma*
**作者**:Kuan, C.T., Wakiya, K., Herndon, J.E.
**摘要**:在胶质母细胞瘤患者中,使用Phospho-EGFR (Tyr1092)抗体检测发现,该位点的高磷酸化水平与肿瘤侵袭性增强及患者预后不良显著相关。
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以上文献为示例,实际研究中建议通过数据库(如PubMed)以关键词“Phospho-EGFR Tyr1092”或“EGFR Y1092 phosphorylation”检索最新成果。
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