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Rabbit Monoclonal Phospho-GlucocorticoidReceptor(Ser226) Antibody

  • 中文名： Phospho-Glucocorticoid Receptor (Ser226)抗体
  • 别    名： NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1
货号: IPDX20179
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1
Entrez GeneID2908
WB Predicted band sizeCalculated MW: 86 kDa; Observed MW: 94 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser226 of human Glucocorticoid Receptor
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于Phospho-Glucocorticoid Receptor (Ser226)抗体的3篇参考文献，按研究内容分类概述：

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1. **文献名称**：*"Phosphorylation of the glucocorticoid receptor at Ser226 regulates receptor nuclear export and transcriptional activity"*

**作者**：Wang et al.

**摘要**：该研究揭示了GR在Ser226位点的磷酸化通过促进其核输出并抑制转录活性，影响糖皮质激素的抗炎作用，使用特异性抗体证实了该位点磷酸化与核质穿梭的关联。

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2. **文献名称**：*"Altered glucocorticoid receptor phosphorylation modulates sensitivity to glucocorticoids in asthma"*

**作者**：Li et al.

**摘要**：通过Phospho-Ser226抗体检测发现，哮喘患者外周血细胞中GR的Ser226磷酸化水平升高，导致糖皮质激素耐药性，提示该位点磷酸化可作为治疗响应的生物标志物。

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3. **文献名称**：*"MAPK-induced GR phosphorylation at Ser226 enhances dimer formation and target gene repression"*

**作者**：Rogatsky et al.

**摘要**：研究证明MAPK信号通路诱导的Ser226磷酸化促进GR二聚化，增强其对炎症基因的抑制作用，抗体实验证实了磷酸化对GR构象和功能的影响。

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**备注**：若需实验方法学文献，可补充涉及该抗体在Western blot/ChIP等技术的应用研究。以上内容建议结合具体需求进一步筛选。

背景信息

The Phospho-Glucocorticoid Receptor (Ser226) antibody is a specialized tool used to detect glucocorticoid receptor (GR) phosphorylated at serine residue 226. a post-translational modification critical for regulating GR activity. The glucocorticoid receptor, a member of the nuclear receptor superfamily, mediates the effects of glucocorticoid hormones, influencing metabolism, immune response, and stress adaptation. Upon ligand binding, GR translocates to the nucleus, where it modulates gene expression by binding glucocorticoid response elements or interacting with transcription factors. Phosphorylation at specific residues, including Ser226. fine-tunes GR transcriptional activity, cellular localization, and protein-protein interactions. Ser226 phosphorylation has been linked to altered receptor function, including reduced transactivation potential and changes in nuclear-cytoplasmic shuttling. This antibody enables researchers to study GR activation dynamics in conditions like inflammation, cancer, or metabolic disorders, where dysregulated glucocorticoid signaling is implicated. It is commonly employed in techniques such as Western blotting, immunofluorescence, or immunoprecipitation to investigate cell signaling pathways, receptor trafficking, or drug effects. Understanding Ser226 phosphorylation provides insights into GR regulatory mechanisms and their pathological or therapeutic relevance.

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