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Rabbit Monoclonal Phospho-GATA3(Ser308) Antibody

  • 中文名： Phospho-GATA3 (Ser308)抗体
  • 别    名： GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3
货号: IPDX20178
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3
Entrez GeneID2625
WB Predicted band sizeCalculated MW: 48 kDa; Observed MW: 48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser308 of human GATA3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇涉及Phospho-GATA3 (Ser308)抗体的参考文献及其摘要内容：

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1. **文献名称**：*"Phosphorylation of GATA3 at Ser308 regulates its transcriptional activity in T cells"*

**作者**：Smith J, et al.

**摘要**：研究揭示了GATA3在T细胞分化中的磷酸化调控机制，发现Ser308位点的磷酸化通过抑制DNA结合能力负调控GATA3的转录活性，并采用Phospho-GATA3 (Ser308)抗体验证了该修饰在Th2细胞中的功能。

2. **文献名称**：*"Post-translational modification of GATA3 in breast cancer progression"*

**作者**：Lee C, et al.

**摘要**：探讨GATA3在乳腺癌中的翻译后修饰，发现Ser308磷酸化与肿瘤转移相关，利用特异性抗体检测磷酸化水平，提示其可作为预后标志物及治疗靶点。

3. **文献名称**：*"A novel signaling axis involving ERK-mediated phosphorylation of GATA3 at Ser308"*

**作者**：Wang H, et al.

**摘要**：报道ERK信号通路通过磷酸化GATA3 Ser308位点促进细胞增殖，研究使用Phospho-GATA3 (Ser308)抗体进行免疫印迹及免疫荧光，证实该修饰在多种癌细胞系中的动态调控。

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注：上述文献为虚拟示例，实际文献需通过PubMed/Google Scholar等平台检索关键词(如“Phospho-GATA3 Ser308”、“GATA3 phosphorylation”)获取。

背景信息

The Phospho-GATA3 (Ser308) antibody is designed to detect GATA3 protein when phosphorylated at serine residue 308. a post-translational modification critical for regulating its transcriptional activity. GATA3. a member of the GATA family of zinc-finger transcription factors, plays essential roles in immune cell development, particularly in T-cell differentiation and T-helper 2 (Th2) cell function. It also contributes to epithelial cell maintenance and is implicated in cancers, including breast cancer. Phosphorylation at Ser308 modulates GATA3’s stability, nuclear localization, and interaction with co-regulators, thereby influencing target gene expression. Studies suggest this modification may be mediated by kinases such as AKT or p38 MAPK under specific signaling conditions. The antibody is widely used in research to investigate Th2-mediated immune responses (e.g., allergies, asthma), cancer progression, and mechanisms of gene regulation. Detection of phosphorylated GATA3 helps clarify its activation state in cellular pathways and disease models. Validated applications include Western blotting, immunofluorescence, and immunohistochemistry, often in conjunction with total GATA3 antibodies to assess phosphorylation dynamics. Its utility extends to both basic research and translational studies exploring therapeutic targets in oncology and immune disorders.

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