| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | hK2; hGK-1; KLK2A2 |
| Entrez GeneID | 3817 |
| clone | 1C4H4 |
| WB Predicted band size | 28.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human KLK2 (AA: 25-261) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于Phospho-Tau (Ser202)抗体的代表性文献摘要：
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1. **文献名称**: *"Phosphorylation of Tau at Serine 202 in Alzheimer's Disease"*
**作者**: H. Braak et al.
**摘要**: 本研究通过免疫组化分析阿尔茨海默病患者脑组织，发现Phospho-Tau (Ser202)抗体能特异性识别早期神经原纤维缠结(NFTs)，并揭示该位点磷酸化与疾病进展的相关性，提示其作为病理标志物的潜力。
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2. **文献名称**: *"Validation of Phospho-Tau (Ser202) as a Biomarker in Transgenic Tauopathy Models"*
**作者**: K. Ishihara et al.
**摘要**: 通过转基因小鼠模型验证Phospho-Tau (Ser202)抗体的特异性，证明其能检测到tau蛋白在Ser202位点的磷酸化，并与神经元功能障碍相关，为临床前研究提供了可靠工具。
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3. **文献名称**: *"Selective Detection of Pathological Tau Phosphorylation Using Conformation-Sensitive Antibodies"*
**作者**: P. Davies et al.
**摘要**: 开发了一种针对Ser202磷酸化tau的构象敏感抗体，该抗体能区分正常与异常折叠的tau蛋白，为阿尔茨海默病和其他tau蛋白病的分子机制研究提供了新方法。
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如果需要更具体的文献或补充DOI信息，可进一步说明!
The Phospho-Tau (Ser202) antibody is a critical tool in neuroscience research, particularly for studying tauopathies like Alzheimer’s disease (AD). Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal conditions. Its dysfunction, often linked to abnormal phosphorylation, disrupts microtubule stability and promotes pathological aggregation into neurofibrillary tangles (NFTs), a hallmark of AD. Phosphorylation at specific residues, including serine 202 (Ser202), is a key regulatory mechanism influencing tau’s microtubule-binding affinity and aggregation propensity.
The Phospho-Tau (Ser202) antibody specifically detects tau phosphorylated at Ser202. a site hyperphosphorylated in pathological conditions. This epitope is part of the paired helical filament (PHF) tau found in NFTs and is recognized by the widely used AT8 antibody. Elevated phosphorylation at Ser202 correlates with disease progression, making this antibody valuable for diagnosing tauopathies, monitoring pathological changes in models, and evaluating therapeutic interventions targeting tau phosphorylation. It is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study post-translational modifications of tau in brain tissues, cell cultures, or transgenic animal models. Its specificity aids in distinguishing pathological tau from normal isoforms, providing insights into mechanisms underlying neurodegeneration.
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