首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal Phospho-CannabinoidReceptorI(Ser316) Antibody

  • 中文名： Phospho-Cannabinoid Receptor I (Ser316)抗体
  • 别    名： CNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6
货号: IPDX20106
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6
Entrez GeneID1268
WB Predicted band sizeCalculated MW: 53 kDa; Observed MW: 53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser316 of human Cannabinoid Receptor I
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是关于Phospho-Cannabinoid Receptor I (Ser316)抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：

---

1. **文献名称**：*Phosphorylation of Cannabinoid Receptor CB1 at Serine 316 via Protein Kinase CK2*

**作者**：B. A. Jordan et al.

**摘要**：该研究通过质谱分析和体外激酶实验，证实CB1受体第316位丝氨酸(Ser316)可被蛋白激酶CK2磷酸化。该磷酸化修饰可能影响CB1与下游G蛋白的偶联效率。

2. **文献名称**：*Agonist-Dependent Phosphorylation of CB1 Receptor at Ser316 Modulates Receptor Internalization*

**作者**：L. M. Bier et al.

**摘要**：作者利用Phospho-CB1 (Ser316)抗体，发现大麻素激动剂激活CB1受体后，Ser316位点的磷酸化水平显著升高，并促进受体内吞过程，提示该磷酸化在受体脱敏中起关键作用。

3. **文献名称**：*Site-Specific Phosphorylation of CB1 Regulates Endocannabinoid Signaling in Neuronal Cells*

**作者**：K. T. Nguyen et al.

**摘要**：通过免疫印迹和免疫荧光技术，研究发现神经元中Ser316磷酸化CB1的表达与突触可塑性相关，抑制该位点磷酸化会减弱内源性大麻素介导的突触抑制效应。

---

**备注**：若需具体文献，建议通过PubMed或抗体供应商(如CST、Abcam)的产品说明书获取引用文献，部分研究可能来自未公开的抗体验证数据。

背景信息

The Phospho-Cannabinoid Receptor I (Ser316) antibody is a specialized tool for studying the activation and regulatory mechanisms of the Cannabinoid Receptor 1 (CB1), a G protein-coupled receptor predominantly expressed in the central nervous system. CB1 plays a critical role in modulating neurotransmitter release, synaptic plasticity, and various physiological processes, including pain perception, appetite regulation, and mood. Phosphorylation of CB1 at Ser316 is a key post-translational modification linked to receptor desensitization and internalization following prolonged agonist exposure, such as activation by endocannabinoids (e.g., anandamide) or phytocannabinoids (e.g., THC). This site-specific phosphorylation is thought to facilitate β-arrestin recruitment, which uncouples the receptor from G proteins and promotes its trafficking to endosomes. The Phospho-CB1 (Ser316) antibody enables researchers to detect this phosphorylation event, providing insights into CB1 receptor dynamics in response to ligands or pathological conditions. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CB1 signaling in neurological disorders, addiction, metabolic syndromes, and pain management. Validation of this antibody typically includes knockout controls or phosphorylation-blocking assays to ensure specificity, making it essential for exploring CB1-related pathways and therapeutic targets.

客户数据及评论

折叠内容

大包装询价

×