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Rabbit Monoclonal Phospho-S6K2(Ser371) Antibody

  • 中文名： Phospho-S6K2 (Ser371)抗体
  • 别    名： RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70
货号: IPDX20093
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70
Entrez GeneID6199
WB Predicted band sizeCalculated MW: 53 kDa; Observed MW: 60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser371 of human P70 S6 Kinase beta
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于 **Phospho-S6K2 (Ser371)** 抗体的参考文献示例(注：以下为假设性文献，实际引用需核实具体来源)：

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1. **文献名称**：*"mTORC1-dependent phosphorylation of S6K2 at Ser371 regulates its kinase activity and cellular localization"*

**作者**：Zhang Y, et al.

**摘要**：本研究揭示了 mTORC1 通过磷酸化 S6K2 的 Ser371 位点调控其激酶活性及核质转位，并利用 Phospho-S6K2 (Ser371) 特异性抗体验证了其在生长因子刺激下的动态磷酸化模式，表明该位点对细胞增殖和蛋白质合成的关键作用。

2. **文献名称**：*"Ser371 phosphorylation of S6K2 is a biomarker for rapamycin sensitivity in cancer cells"*

**作者**：Lee HJ, et al.

**摘要**：通过免疫印迹(使用 Phospho-S6K2 Ser371 抗体)和功能实验，证明 Ser371 磷酸化水平与肿瘤细胞对 mTOR 抑制剂雷帕霉素的敏感性相关，为靶向治疗提供了潜在标志物。

3. **文献名称**：*"Role of S6K2 phosphorylation at Ser371 in skeletal muscle hypertrophy"*

**作者**：Smith JR, et al.

**摘要**：研究利用特异性抗体证实，在肌肉肥大模型中，S6K2 的 Ser371 磷酸化通过激活下游翻译调控因子促进蛋白质合成，提示其在运动适应性中的生理意义。

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**备注**：以上文献为示例，实际引用需查询 PubMed 或抗体供应商(如 CST、Abcam)提供的参考文献列表。建议通过关键词 **"S6K2 phosphorylation Ser371"** 或抗体货号在学术数据库中检索具体文献。

背景信息

The Phospho-S6K2 (Ser371) antibody is a specialized tool used to detect the phosphorylated form of ribosomal protein S6 kinase beta-2 (S6K2) at serine residue 371. S6K2. a member of the AGC kinase family, is a downstream effector of the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway, which regulates cell growth, proliferation, and survival in response to nutrients, growth factors, and cellular stress. Phosphorylation at Ser371 is associated with S6K2 activation, though its exact role in kinase activity remains less characterized compared to other phosphorylation sites like Thr388/389. This antibody enables researchers to study S6K2 activation dynamics under conditions such as mTOR inhibition (e.g., rapamycin treatment) or growth factor stimulation. It is widely used in Western blotting, immunofluorescence, and immunohistochemistry to investigate mTOR pathway activity in diseases like cancer, metabolic disorders, and aging-related conditions. Specificity for the phosphorylated Ser371 epitope distinguishes it from non-phosphorylated S6K2 or its isoform S6K1. aiding in precise pathway analysis. Validations often include testing in cell lines with mTOR pathway modulators or genetic knockouts to confirm target specificity.

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