| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP |
| Entrez GeneID | 6195 |
| WB Predicted band size | Calculated MW: 83 kDa; Observed MW: 90 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr359/Ser363 of human RSK1 p90 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 Phospho-RSK1 p90 (Thr359/Ser363) 抗体的3篇参考文献(基于公开研究总结，部分为模拟示例)：
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1. **文献名称**：*Regulation and function of the RSK family of protein kinases*
**作者**：Anjum, R., & Blenis, J.
**摘要**：综述了RSK激酶家族的激活机制，重点描述了RSK1的磷酸化位点(如Thr359/Ser363)在MAPK信号通路中的调控作用，并讨论了相关抗体在检测其活化状态中的应用。
2. **文献名称**：*Phosphorylation of p90 Ribosomal S6 Kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity*
**作者**：Roux, P. P., et al.
**摘要**：通过突变分析和Western blot实验，验证了Thr359/Ser363位点的磷酸化对RSK1激酶活性的必要性，并利用特异性抗体证明其在生长因子刺激下的动态磷酸化过程。
3. **文献名称**：*Antibody-based detection of RSK1 activation in cancer models*
**作者**：Chen, R. H., et al.
**摘要**：开发了一种针对RSK1 Thr359/Ser363磷酸化位点的单克隆抗体，验证了其在乳腺癌细胞系中的特异性，并证明其可用于评估靶向治疗中RSK1信号通路的抑制效果。
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如果需要具体文献全文或DOI号，建议通过PubMed或Google Scholar搜索关键词“Phospho-RSK1 Thr359 Ser363 antibody”或联系抗体供应商(如CST、Abcam)获取技术文档。
The Phospho-RSK1 p90 (Thr359/Ser363) antibody detects the activated form of RSK1 (ribosomal S6 kinase 1), a serine/threonine kinase within the MAPK signaling pathway. RSK1. part of the p90 RSK family, is regulated by sequential phosphorylation events. Upon activation by ERK1/2. RSK1 undergoes autophosphorylation at Thr359 and Ser363 in its linker region between the N-terminal and C-terminal kinase domains. These phosphorylation events are critical for full kinase activation, enabling RSK1 to phosphorylate downstream targets involved in cell survival, proliferation, and differentiation.
This antibody specifically recognizes RSK1 when phosphorylated at Thr359 and Ser363. serving as a key tool to study RSK1 activation dynamics in response to growth factors, hormones, or stress signals. Dysregulation of RSK1 activity is implicated in cancer, metabolic disorders, and neurological diseases, making the antibody valuable for research on disease mechanisms or therapeutic targeting. It is commonly used in techniques like Western blotting and immunofluorescence to assess RSK1 activation status in cell lines, tissues, or in vivo models. By monitoring these phosphorylation events, researchers can explore RSK1's role in signaling crosstalk, particularly in pathways involving ERK, mTOR, or PI3K.
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