| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABP32; PEF; pef1; PEF1A; Peflin;;Peflin |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Peflin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PEF1抗体的3篇参考文献示例(内容为虚构，仅供参考格式)：
1. **文献名称**: *PEF1 regulates mitotic spindle assembly through antibody-mediated functional analysis*
**作者**: Smith S, et al.
**摘要**: 研究利用PEF1抗体揭示其在调控有丝分裂纺锤体形成中的作用，证实PEF1缺失导致染色体分离异常。
2. **文献名称**: *PEF1 expression in neurodegenerative disorders: An immunohistochemical study*
**作者**: Doe J, et al.
**摘要**: 通过PEF1抗体检测阿尔茨海默病模型中的蛋白表达，发现其与tau蛋白异常聚集存在相关性。
3. **文献名称**: *Development of a monoclonal PEF1 antibody for cancer biomarker screening*
**作者**: Lee A, et al.
**摘要**: 报道一种高特异性PEF1单克隆抗体的开发，并验证其在结直肠癌组织中的诊断潜力。
4. **文献名称**: *PEF1 interaction with apoptosis signaling pathways: Evidence from co-immunoprecipitation assays*
**作者**: Brown M, et al.
**摘要**: 利用PEF1抗体进行免疫共沉淀实验，揭示其与Bcl-2家族蛋白的相互作用，调控细胞凋亡过程。
(注：以上文献为模拟示例，实际需通过学术数据库检索具体研究。)
The PEF1 (Plasticity-Related Gene 1) antibody is a research tool targeting the PEF1 protein, encoded by the PEF1 gene located on human chromosome 1p36.13. PEF1. also known as Partner of ENDOGENOUS RETROVIRUS GROUP 1 (PEG1) or Zymogen Granule Protein 16 (ZG16), is a calcium-binding protein implicated in synaptic plasticity, neuronal development, and intracellular signaling. Structurally, it contains an EF-hand calcium-binding domain, suggesting a role in calcium-mediated processes. Studies highlight its expression in the brain, particularly the hippocampus and cortex, linking it to learning, memory, and neurodegenerative disorders like Alzheimer’s disease. PEF1 also associates with cancer progression, showing altered expression in colorectal and gastric cancers.
The PEF1 antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to detect PEF1 expression levels and localization in tissues or cell lines. Its applications extend to exploring PEF1’s interaction with synaptic proteins, calcium-dependent pathways, and its potential as a biomarker in neurological or oncological research. Commercial variants include monoclonal and polyclonal antibodies from species like rabbit or mouse. However, validation steps (e.g., knockout controls) are critical due to potential cross-reactivity. Ongoing research focuses on clarifying PEF1’s dual roles in neuroprotection and tumorigenesis, making this antibody pivotal in elucidating its molecular mechanisms and therapeutic potential.
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