| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MIP2A; SEDL; Sedlin; SEDLP; SEDT; Trafficking protein particle complex 2; TRAPPC2P1; TRS20; ZNF547L;;TRAPPC2 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TRAPPC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TRAPPC2抗体的3篇参考文献示例(注：文献信息为假设性示例，实际文献需通过学术数据库查询验证)：
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1. **文献名称**: *TRAPPC2 mutations in skeletal dysplasia: Functional analysis using a novel antibody*
**作者**: Bogershausen, N., et al.
**摘要**: 研究通过开发特异性TRAPPC2抗体，分析了其在成纤维细胞中的表达与定位，发现突变导致蛋白稳定性下降，揭示了其在骨骼发育中的关键作用。
2. **文献名称**: *Characterization of TRAPPC2 interactions in vesicular trafficking by co-immunoprecipitation*
**作者**: Venditti, R., et al.
**摘要**: 利用TRAPPC2抗体进行免疫共沉淀实验，证明其与TRAPP复合体其他亚基的相互作用，阐明其在细胞内运输中的调控机制。
3. **文献名称**: *Altered TRAPPC2 expression in spondyloepiphyseal dysplasia patients: A diagnostic biomarker study*
**作者**: Liedtke, D., et al.
**摘要**: 通过Western blot和免疫组化检测患者样本，发现TRAPPC2抗体可有效区分突变携带者，提出其作为SEDT诊断工具的潜力。
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**提示**：实际研究中建议通过PubMed或Google Scholar检索关键词“TRAPPC2 antibody”或“TRAPPC2 AND (Western blot/immunofluorescence)”，筛选近年高影响力文献，并关注其抗体货号(如Santa Cruz的sc-12345)以复现实验。
The TRAPPC2 antibody is a crucial tool for studying the Trafficking Protein Particle Complex 2 (TRAPPC2), a component of the multi-subunit TRAPP (Transport Protein Particle) complexes involved in intracellular membrane trafficking. TRAPPC2. also known as Sedlin, plays a role in vesicle-mediated transport between the Golgi apparatus and endoplasmic reticulum, influencing cargo sorting, organelle maintenance, and autophagy. Mutations in the TRAPPC2 gene are linked to X-linked spondyloepiphyseal dysplasia tarda (SEDT), a skeletal disorder characterized by abnormal bone growth.
TRAPPC2 antibodies are widely used to investigate protein expression, localization, and interactions in cellular models. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are typically raised in hosts such as rabbits or mice, with validation including knockout cell line controls to ensure specificity. Researchers employ TRAPPC2 antibodies to explore its role in diseases beyond SEDT, including cancers and neurological disorders, where disrupted vesicular trafficking contributes to pathogenesis.
Recent studies also highlight TRAPPC2's involvement in ciliogenesis and mTOR signaling, expanding its relevance in developmental biology and metabolic regulation. Commercial availability of monoclonal and polyclonal TRAPPC2 antibodies supports diverse experimental needs, though batch validation remains critical due to potential cross-reactivity with other TRAPP subunits. Overall, TRAPPC2 antibodies are indispensable for dissecting molecular mechanisms underlying cellular trafficking and associated pathologies.
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