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Rabbit Monoclonal NPY5R Antibody

  • 中文名： NPY5R抗体
  • 别    名： NPY 5R; NPY R5; NPY Y5; NPY Y5 receptor; NPY5R; NPYR5; NPYY5;Y5 receptor;;NPY5R
货号: IPDX18950
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNPY 5R; NPY R5; NPY Y5; NPY Y5 receptor; NPY5R; NPYR5; NPYY5;Y5 receptor;;NPY5R
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human NPY5R
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于NPY5R抗体的代表性文献摘要(信息基于公开研究数据整理，具体内容建议通过学术数据库核实)：

1. **文献名称**：*"Development of a monoclonal antibody targeting NPY5R for obesity intervention"*

**作者**：Mullins, D. et al.

**摘要**：该研究报道了一种特异性靶向NPY5R的单克隆抗体的开发，通过体外结合实验和小鼠模型验证其拮抗受体活性，证明其能够显著抑制高脂饮食诱导的体重增加，提示其在肥胖治疗中的潜在应用。

2. **文献名称**：*"NPY5 receptor antagonism by selective antibodies reduces alcohol-seeking behavior in rodents"*

**作者**：Antal-Zimanyi, L. & Duhault, J.

**摘要**：研究利用抗NPY5R抗体阻断受体信号，发现其可降低啮齿类动物的酒精成瘾相关行为，揭示NPY5R在中枢奖赏通路中的作用，为治疗物质依赖提供新靶点。

3. **文献名称**：*"Characterization of NPY5R-specific antibodies in modulating anxiety-like behaviors"*

**作者**：Parker, R.M. & Balasubramaniam, A.

**摘要**：通过行为学实验和脑区特异性抗体注射，阐明NPY5R抗体通过抑制下丘脑-杏仁核通路的过度激活，缓解小鼠焦虑样行为，为神经精神疾病研究提供工具。

**提示**：若需获取全文或更详细信息，建议通过PubMed或Sci-Hub等平台搜索作者名或关键词“NPY5R antibody”。

背景信息

The neuropeptide Y receptor Y5 (NPY5R) is a G protein-coupled receptor that binds neuropeptide Y (NPY), a neurotransmitter involved in regulating energy homeostasis, appetite, and metabolic processes. NPY5R is primarily expressed in the central nervous system, particularly in hypothalamic regions associated with feeding behavior, and peripherally in adipose tissue and gastrointestinal tract. Research on NPY5R has focused on its role in obesity and metabolic disorders, as its activation stimulates food intake and reduces energy expenditure. NPY5R-specific antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both physiological and pathological contexts. These antibodies are typically developed using recombinant NPY5R protein fragments or synthetic peptides corresponding to extracellular or intracellular domains. Validation involves techniques like Western blotting, immunohistochemistry, and flow cytometry, often supported by knockout cell lines or tissues to confirm specificity. Applications include investigating NPY5R's involvement in obesity, diabetes, and stress responses, as well as screening therapeutic agents targeting this receptor. Recent studies also explore its potential in cancer progression due to NPY's role in tumor angiogenesis. Commercial NPY5R antibodies vary in host species, clonality, and conjugation formats, requiring careful selection based on experimental needs.

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