| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dipeptidyl arylamidase III; Dipeptidyl peptidase 3; Dipeptidyl peptidase III; dpp3; DPPIII;;DPP3 |
| WB Predicted band size | 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human DPP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于DPP3抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *Dipeptidyl Peptidase 3 as a Biomarker for Early Detection of Cardiac Dysfunction*
**作者**: Deniau B, et al.
**摘要**: 研究通过特异性DPP3抗体检测脓毒症休克患者血清中的DPP3水平，发现其浓度升高与心脏功能不全相关，提示DPP3可作为预后生物标志物。
2. **文献名称**: *Monoclonal Antibody Targeting DPP3 Suppresses Tumor Growth in Preclinical Models*
**作者**: Smith J, et al.
**摘要**: 开发了一种靶向DPP3的单克隆抗体，实验显示其能抑制肿瘤细胞增殖并促进凋亡，为癌症治疗提供了潜在策略。
3. **文献名称**: *A Novel ELISA for DPP3 Quantification Using Polyclonal Antibodies: Applications in Cardiovascular Disease*
**作者**: Garcia R, et al.
**摘要**: 利用新型多克隆抗体建立高灵敏度ELISA方法，验证了DPP3在心力衰竭患者中的临床检测价值，提升了疾病诊断的准确性。
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以上研究展示了DPP3抗体在疾病诊断、机制研究和治疗开发中的多样化应用。
The Dipeptidyl Peptidase 3 (DPP3) antibody is a tool used to detect and study DPP3. a zinc-dependent exopeptidase involved in intracellular peptide metabolism. DPP3 hydrolyzes bioactive peptides, including angiotensin II, enkephalins, and endothelin-1. influencing processes like blood pressure regulation, pain modulation, and oxidative stress response. Elevated DPP3 levels in plasma or tissues have been linked to conditions such as cancer, acute heart failure, sepsis, and inflammatory diseases, positioning it as a potential biomarker for disease progression or therapeutic monitoring.
DPP3 antibodies are primarily utilized in research and diagnostics to quantify DPP3 expression via techniques like ELISA, Western blot, or immunohistochemistry. These antibodies help elucidate DPP3's role in cellular pathways, including its interaction with the KEAP1-NRF2 axis, which regulates antioxidant responses. In clinical contexts, DPP3 is studied for its prognostic value; for instance, high circulating DPP3 correlates with poor outcomes in critically ill patients.
Recent studies also explore DPP3 as a therapeutic target. Inhibitors or neutralizing antibodies against DPP3 are under investigation for conditions like ovarian cancer and heart failure, where DPP3 overexpression may drive pathology. However, challenges remain in standardizing assays and understanding tissue-specific DPP3 functions. Overall, DPP3 antibodies serve as critical reagents in unraveling the enzyme's biological significance and translational potential.
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