| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CGI 51; OMP85; SAM50; Samm50; TOB55;;SAMM50 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SAMM50 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3条关于SAMM50抗体的研究文献摘要概括(虚构示例，仅供格式参考)：
1. **文献名称**：《SAMM50调控线粒体自噬的分子机制》
**作者**：Zhang et al.
**摘要**：研究通过SAMM50抗体进行免疫共沉淀实验，发现SAMM50与MFN1蛋白互作，调控线粒体分裂和自噬过程，缺失导致肝细胞脂质积累。
2. **文献名称**：《SAMM50在非酒精性脂肪肝中的表达及意义》
**作者**：Wang et al.
**摘要**：利用SAMM50抗体进行Western blot和免疫组化分析，证实SAMM50在NAFLD患者肝组织中表达下调，与线粒体功能障碍和炎症相关。
3. **文献名称**：《SAMM50基因敲除小鼠模型的代谢表型分析》
**作者**：Kimura et al.
**摘要**：通过SAMM50抗体验证蛋白敲除效率，发现小鼠出现线粒体结构异常和能量代谢紊乱，提示SAMM50在维持线粒体稳态中的关键作用。
(注：以上文献为模拟示例，实际文献需通过PubMed等数据库检索确认。)
The SAMM50 (Sorting and Assembly Machinery component 50) antibody is a crucial tool for studying the SAMM50 protein, a mitochondrial membrane-associated protein involved in maintaining mitochondrial structure and function. SAMM50 is a core component of the mitochondrial outer membrane sorting and assembly machinery (SAM complex), which facilitates the proper integration of beta-barrel proteins into the mitochondrial outer membrane. It plays a role in mitochondrial dynamics, cristae morphology, and lipid metabolism, particularly in cardiolipin remodeling.
Antibodies targeting SAMM50 are widely used in research applications such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and interactions. These antibodies help elucidate SAMM50's role in mitochondrial quality control, oxidative phosphorylation, and apoptosis. Dysregulation of SAMM50 has been linked to mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s), metabolic syndromes, and cancers, making its study vital for understanding disease mechanisms.
Commercial SAMM50 antibodies are typically validated for specificity using knockout cell lines or tissues. Researchers rely on them to explore mitochondrial dysfunction pathways, assess cellular stress responses, or screen for therapeutic targets. Proper validation and controls are essential due to potential cross-reactivity with homologous proteins or isoforms.
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