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Rabbit Monoclonal TUG Antibody

  • 中文名： TUG抗体
  • 别    名： ASPC; ASPCR1; ASPL; ASPS; Aspscr1; RCC17; TUG; UBXD9; UBXN9;;TUG
货号: IPDX18924
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesASPC; ASPCR1; ASPL; ASPS; Aspscr1; RCC17; TUG; UBXD9; UBXN9;;TUG
WB Predicted band sizeCalculated MW: 60 kDa ; Observed MW: 70-80 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human TUG
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TUG(Tethering UBA-containing protein in Golgi)抗体的参考文献示例(注：部分文献信息为示例性虚构，实际文献需通过学术数据库验证)：

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1. **文献名称**: *TUG Antibody Reveals Role in GLUT4 Vesicle Trafficking in Adipocytes*

**作者**: Smith J, et al.

**摘要**: 本研究利用TUG特异性抗体，揭示了TUG蛋白在脂肪细胞中调控GLUT4葡萄糖转运体囊泡运输的作用机制，表明TUG通过结合Ubiquitin-like结构域介导胰岛素信号通路响应。

2. **文献名称**: *TUG as a Biomarker in Glioblastoma: Validation via Immunohistochemistry*

**作者**: Lee H, et al.

**摘要**: 通过开发高特异性TUG单克隆抗体，研究发现TUG在胶质母细胞瘤组织中异常高表达，并与患者预后不良相关，提示其作为潜在治疗靶点的可能性。

3. **文献名称**: *TUG Antibody-Based Screening Identifies Dysregulation in Neurodegenerative Models*

**作者**: Chen R, et al.

**摘要**: 利用TUG抗体对阿尔茨海默病模型小鼠脑组织进行分析，发现TUG蛋白与tau蛋白异常聚集存在共定位，提示其在神经退行性疾病中的病理调控作用。

4. **文献名称**: *Structural Analysis of TUG Protein Interactions Using Epitope-Specific Antibodies*

**作者**: Gonzalez M, et al.

**摘要**: 通过表位特异性TUG抗体的结构生物学研究，解析了TUG蛋白与高尔基体相关蛋白UBXD8的结合界面，为靶向TUG的药物设计提供了分子基础。

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**说明**：以上文献为示例性内容，实际研究中请通过PubMed、Google Scholar等平台检索关键词(如“TUG antibody”“TUG protein function”)获取真实文献。若需具体文献协助，请进一步说明研究方向(如疾病领域或分子机制)。

背景信息

The TUG (Taurine Upregulated Gene) antibody targets a protein encoded by the TUG gene, initially identified for its upregulation by taurine in developing retinal cells. TUG protein plays a critical role in intracellular vesicle trafficking, particularly in the translocation of glucose transporter GLUT4 to the plasma membrane in response to insulin. This process is essential for cellular glucose uptake, linking TUG to metabolic regulation and insulin sensitivity. Structurally, TUG contains a conserved "TC motif" that interacts with other trafficking proteins, such as the SNARE complex, facilitating vesicle fusion. Research on TUG antibodies has advanced studies in diabetes, obesity, and metabolic syndromes, as disrupted TUG function correlates with insulin resistance. Additionally, TUG is implicated in neuronal development and cancer, where altered expression affects cell proliferation and survival. The antibody serves as a vital tool for detecting TUG in tissues, elucidating its spatial expression and interaction networks. Recent studies also explore its role in autophagy and stress responses, broadening its relevance in pathophysiology. TUG antibodies thus underpin both basic mechanistic research and therapeutic exploration, highlighting their importance in understanding metabolic and degenerative diseases.

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