| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ZNF259; ZPR1;;ZPR1 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ZPR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4篇与ZNF259抗体相关的参考文献示例(内容为模拟，供参考)：
1. **标题**：*ZNF259 variants associate with type 2 diabetes and lipid metabolism*
**作者**：Smith A, et al.
**摘要**：通过GWAS研究发现ZNF259基因多态性与2型糖尿病及血脂异常相关，研究采用ZNF259抗体进行Western blot和免疫组化分析，证实其在肝脏和脂肪组织中的蛋白表达水平与代谢表型相关。
2. **标题**：*ZNF259 promotes glioblastoma progression via epigenetic regulation*
**作者**：Chen L, et al.
**摘要**：研究揭示ZNF259通过结合特定DNA序列调控胶质母细胞瘤相关基因的转录，利用ZNF259抗体进行ChIP-seq实验，鉴定其靶向基因并发现其与患者预后不良相关。
3. **标题**：*KRAB-ZFP family member ZNF259 suppresses viral response pathways*
**作者**：Kimura Y, et al.
**摘要**：通过siRNA敲低和ZNF259抗体介导的免疫沉淀实验，发现ZNF259通过抑制干扰素信号通路参与宿主抗病毒反应调控，为自身免疫疾病治疗提供新靶点。
4. **标题**：*ZNF259 antibody validation in adipocyte differentiation models*
**作者**：Wang X, et al.
**摘要**：研究验证了ZNF259抗体在脂肪细胞分化模型中的特异性，并发现ZNF259通过调控PPARγ表达影响脂肪生成，为代谢疾病机制研究提供工具支持。
(注：以上文献为示例，实际引用需根据具体研究检索PubMed、Google Scholar等数据库获取真实文献。)
The ZNF259 antibody is a research tool designed to detect ZNF259. a protein encoded by the *ZNF259* gene in humans. Also known as ZSCAN5B (zinc finger and SCAN domain-containing protein 5B), ZNF259 belongs to the zinc finger protein family, characterized by conserved C2H2-type zinc finger motifs involved in DNA binding and transcriptional regulation. ZNF259 is thought to play roles in transcriptional control, potentially influencing cellular processes like differentiation, proliferation, and genome stability. Its exact biological functions, however, remain under active investigation.
Antibodies targeting ZNF259 are commonly used in molecular biology to study its expression, localization, and interactions. These antibodies enable techniques such as Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP), helping researchers map its tissue distribution, subcellular localization (primarily nuclear), and association with chromatin or other proteins. ZNF259 has been implicated in studies related to stem cell biology, cancer research, and developmental disorders, with some evidence suggesting its involvement in maintaining pluripotency or regulating oncogenic pathways.
Commercial ZNF259 antibodies are typically validated for specificity and sensitivity using knockout cell lines or siRNA-mediated knockdown. Researchers must verify cross-reactivity with homologous proteins, as zinc finger domains often share structural similarities. Continued interest in ZNF259 stems from its potential as a biomarker or therapeutic target in diseases linked to transcriptional dysregulation.
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