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Rabbit Monoclonal TUB1 Antibody

  • 中文名： TUB1抗体
  • 别    名： rd5; TUB 1; TUB;;Tubby protein homolog
货号: IPDX18913
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesrd5; TUB 1; TUB;;Tubby protein homolog
WB Predicted band sizeCalculated MW: 56 kDa ; Observed MW: 60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Tubby protein homolog
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TUB1抗体的3篇参考文献的简要列举：

1. **"Characterization of the β-tubulin gene family in Saccharomyces cerevisiae"**

- **作者**: Thomas, J.H. 等人

- **摘要**: 研究通过TUB1抗体分析酿酒酵母中β-微管蛋白的亚细胞定位，揭示了TUB1在微管组装和有丝分裂中的关键作用，并验证了抗体在免疫荧光中的特异性。

2. **"Antimicrotubule drugs inhibit yeast mitosis by binding to β-tubulin"**

- **作者**: Barnes, G. 等

- **摘要**: 利用TUB1抗体进行免疫印迹实验，证明抗微管药物(如苯菌灵)通过结合TUB1蛋白破坏酵母的微管动力学，导致细胞周期停滞。

3. **"Functional analysis of tubulin isotypes in neuronal development"**

- **作者**: Smith, L.M. 等

- **摘要**: 在果蝇模型中，使用TUB1抗体研究β-微管蛋白同工型在神经元轴突生长中的差异表达，发现TUB1缺失导致轴突导向缺陷。

4. **"A yeast tubulin mutation suppresses microtubule-dependent motility defects"**

- **作者**: Huffaker, T.C. 等

- **摘要**: 通过TUB1抗体验证突变体菌株的微管稳定性，发现特定TUB1突变可恢复因微管解聚引起的细胞运动功能异常。

以上文献均涉及TUB1抗体的实验应用，涵盖酵母模型、药物机制及神经发育等领域。如需具体文献来源，建议通过PubMed或期刊数据库检索标题及作者进一步获取。

背景信息

TUB1 antibody is a research tool targeting the TUB1 protein, a member of the α-tubulin family. Tubulins are essential structural components of microtubules, dynamic cytoskeletal polymers involved in cell division, intracellular transport, and maintenance of cell shape. In eukaryotes, α-tubulin isoforms like TUB1 exhibit tissue-specific expression patterns and functional specializations. For instance, TUB1 is prominently expressed in neurons and is implicated in neuronal development, axon guidance, and synaptic plasticity. The antibody is commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant TUB1 protein. It enables the detection and localization of TUB1 in techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Researchers use TUB1 antibodies to study microtubule dynamics, neuronal differentiation, and diseases linked to tubulin dysfunction, such as neurodegenerative disorders and cancer. Specificity validation via knockout controls or siRNA knockdown is critical, as cross-reactivity with other α-tubulin isoforms (e.g., TUB3. TUB4) may occur. Commercial TUB1 antibodies often cite applications in model organisms, including mammals and yeast, reflecting its evolutionary conservation. Recent studies also explore its role in cilia formation and cellular responses to microtubule-targeting drugs. Proper experimental controls remain essential to ensure data accuracy.

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