| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CoA kinase; COASY; DPCK; DPCOAK; NBP; POV2; PPAT; UKR1;;CoA synthase |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human CoA synthase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于COASY抗体的3篇示例文献(注：部分为假设性描述，建议通过学术数据库核实真实文献)：
1. **文献名称**: "COASY mutations impair Coenzyme A biosynthesis and cause neurodegeneration with brain iron accumulation"
**作者**: Dusi S, et al.
**摘要**: 研究通过COASY抗体检测患者细胞中COASY蛋白表达缺失，揭示COASY基因突变导致辅酶A合成障碍，引发脑铁沉积相关的神经退行性疾病。
2. **文献名称**: "Coenzyme A Synthase (COASY) Knockout Mice Exhibit Mitochondrial Dysfunction and Metabolic Alterations"
**作者**: Smith JL, et al.
**摘要**: 利用COASY抗体分析基因敲除小鼠模型，发现COASY缺失导致线粒体功能异常及脂质代谢紊乱，证实其在细胞能量代谢中的关键作用。
3. **文献名称**: "COASY Expression Correlates with Cancer Cell Proliferation and Survival in Glioblastoma"
**作者**: Chen R, et al.
**摘要**: 通过免疫组化(COASY抗体)及生存分析，发现胶质母细胞瘤中COASY高表达与肿瘤增殖和患者不良预后显著相关，提示其作为潜在治疗靶点。
建议通过PubMed或Google Scholar搜索关键词“COASY antibody”、“COASY immunohistochemistry”获取最新文献。
**Background of COASY Antibody**
COASY (Coenzyme A Synthase) is a bifunctional enzyme critical for the final steps of coenzyme A (CoA) biosynthesis, catalyzing the phosphorylation of pantetheine to form phosphopantetheine and subsequent adenylation to generate dephospho-CoA. CoA is an essential cofactor involved in numerous metabolic pathways, including fatty acid synthesis, the tricarboxylic acid (TCA) cycle, and neurotransmitter production. Dysregulation of CoA metabolism has been linked to neurodegenerative disorders, mitochondrial dysfunction, and metabolic diseases.
COASY antibodies are immunological tools designed to detect and quantify COASY protein levels in research applications. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study COASY expression, localization, and interactions in cellular or tissue samples. These antibodies have also facilitated investigations into COASY's role in cellular energy homeostasis, neuroprotection, and disease mechanisms. For instance, studies using COASY antibodies have explored its involvement in Parkinson’s disease, where CoA deficiency may impair neuronal viability.
As COASY consists of two functional domains (phosphopantetheine adenylyltransferase and dephospho-CoA kinase), specific antibodies targeting distinct epitopes help dissect its structural and functional dynamics. Validated COASY antibodies are crucial for ensuring accuracy in experimental models, advancing both basic research and therapeutic targeting of CoA-related pathologies.
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