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Rabbit Monoclonal MGST1 Antibody

  • 中文名： MGST1抗体
  • 别    名： MGST1; GST12; MGST; MGST I; MGST1; ;Microsomal GST 1
货号: IPDX18908
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMGST1; GST12; MGST; MGST I; MGST1; ;Microsomal GST 1
WB Predicted band sizeCalculated MW: 18 kDa ; Observed MW: 15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Microsomal GST 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于MGST1抗体的3篇虚构参考文献示例(仅供格式参考，实际文献需根据真实研究补充)：

1. **文献名称**：*"Characterization of MGST1 in oxidative stress response using specific polyclonal antibodies"*

**作者**：Morgenstern R, et al.

**摘要**：研究通过制备兔源多克隆抗体，验证MGST1在肝细胞中的表达及其在脂质过氧化中的保护作用，抗体用于Western blot和免疫荧光定位。

2. **文献名称**：*"MGST1 overexpression in cancer: Immunohistochemical analysis with a novel monoclonal antibody"*

**作者**：Jakobsson PJ, et al.

**摘要**：开发了一种小鼠单克隆抗体，用于检测肿瘤组织中MGST1的异常表达，发现其与化疗耐药性相关。

3. **文献名称**：*"Role of MGST1 in mitochondrial membrane protection: Insights from antibody-based inhibition studies"*

**作者**：Singh S, et al.

**摘要**：通过特异性抗体阻断MGST1功能，证明其在维持线粒体膜稳定性及调控凋亡中的关键作用。

建议通过PubMed或Google Scholar检索真实文献，关键词如“MGST1 antibody”或“MGST1 immunohistochemistry”。

背景信息

The MGST1 (Microsomal Glutathione S-Transferase 1) antibody is a tool used to study the MGST1 protein, a member of the membrane-associated proteins in the eicosanoid and glutathione metabolism (MAPEG) family. MGST1 is a key enzyme involved in cellular detoxification and antioxidant defense, catalyzing the conjugation of glutathione to electrophilic substrates, thereby neutralizing reactive oxygen species (ROS) and toxic compounds. It is localized to the endoplasmic reticulum and mitochondrial-associated membranes, playing a critical role in maintaining redox homeostasis. Dysregulation of MGST1 has been implicated in various pathologies, including cancer, neurodegenerative diseases, and drug resistance, as its overexpression can enhance cell survival under oxidative stress or chemotherapy. Researchers utilize MGST1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and function in tissues or cell lines. These antibodies are essential for understanding MGST1's role in cellular stress responses, apoptosis regulation, and disease mechanisms. Validation of antibody specificity—through knockdown experiments or knockout controls—is crucial to ensure accurate detection, given potential cross-reactivity with other GST family members. Commercial MGST1 antibodies are available from multiple suppliers, often with species-specific reactivity (e.g., human, mouse, rat). Its study remains vital for exploring therapeutic strategies targeting oxidative stress-related disorders.

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