| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UDRPASE; UPase 1; UPASE; UPP; Upp1; UrdPase 1;;Uridine phosphorylase 1 |
| WB Predicted band size | Calculated MW: 34 kDa ; Observed MW: 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Uridine phosphorylase 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及UPP1抗体的代表性文献摘要(内容为模拟整合，供参考)：
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1. **文献名称**: *UPP1 promotes colorectal cancer progression through pyrimidine metabolism*
**作者**: Zhang Y et al.
**摘要**: 本研究通过免疫组化(使用UPP1抗体)发现UPP1在结直肠癌组织中高表达，并通过调控嘧啶代谢促进肿瘤细胞增殖和转移，提示UPP1可能作为潜在治疗靶点。
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2. **文献名称**: *Uridine phosphorylase 1 as a prognostic biomarker in pancreatic cancer*
**作者**: Huang L et al.
**摘要**: 通过Western blot和免疫荧光(基于UPP1抗体)证实胰腺癌中UPP1表达与患者生存率负相关，其通过调节5-FU耐药性影响化疗效果，为预后评估提供依据。
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3. **文献名称**: *Targeting UPP1 enhances chemosensitivity in hepatocellular carcinoma*
**作者**: Chen X et al.
**摘要**: 利用UPP1抗体检测肝癌细胞系中蛋白表达，发现抑制UPP1可增强顺铂敏感性，机制涉及嘧啶代谢重编程和线粒体凋亡通路激活。
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**注**：以上文献信息为示例，实际引用需根据具体研究通过PubMed或Google Scholar检索确认。建议使用关键词“UPP1 antibody”、“uridine phosphorylase 1 cancer”等筛选近年实验性论文或权威综述。
**Background of UPP1 Antibody**
Uridine phosphorylase 1 (UPP1) is an enzyme encoded by the *UPP1* gene, primarily involved in pyrimidine metabolism by catalyzing the reversible phosphorylation of uridine to uracil and ribose-1-phosphate. This enzyme plays a critical role in nucleotide salvage pathways, influencing cellular proliferation and survival. UPP1 is highly expressed in certain cancers, including colorectal, pancreatic, and hepatocellular carcinomas, where it is associated with aggressive tumor behavior and poor prognosis. Its overexpression is linked to enhanced pyrimidine recycling, supporting rapid cancer cell growth and resistance to chemotherapeutic agents like 5-fluorouracil (5-FU).
The UPP1 antibody is a valuable tool for detecting UPP1 protein levels in research and diagnostics. It enables the study of UPP1's role in tumor metabolism, drug resistance, and potential as a therapeutic target. Applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess UPP1 expression patterns in tissues or cell lines. Recent studies also explore UPP1's involvement in immune modulation and its interaction with tumor microenvironments. As interest grows in targeting metabolic enzymes for cancer therapy, UPP1 antibodies contribute to elucidating mechanisms of UPP1 inhibition and evaluating novel therapeutic strategies.
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