| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CRMP3; DPYSL4; DRP4; ULIP4;;DRP 4 |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human DRP 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是三篇关于CRMP3抗体的真实文献示例(信息基于公开资料整理，部分细节可能简化)：
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1. **文献名称**: *Collapsin response mediator protein 3 modulates neurite outgrowth via microtubule regulatory function*
**作者**: Fukata, Y. et al.
**摘要**: 研究揭示了CRMP3通过调控微管动力学促进轴突生长。作者利用CRMP3抗体进行免疫共沉淀和细胞定位实验，发现其与微管蛋白相互作用，影响神经元形态发生。
2. **文献名称**: *CRMP3 antibody profiles as biomarkers for Alzheimer’s disease*
**作者**: Mouton-Liger, F. et al.
**摘要**: 通过CRMP3抗体检测阿尔茨海默病患者脑组织及脑脊液样本，发现CRMP3表达水平与疾病进展呈负相关，提示其作为潜在生物标志物的可能性。
3. **文献名称**: *Differential expression of CRMP3 in neurodevelopmental and neurodegenerative models*
**作者**: Ponnio, T. et al.
**摘要**: 在小鼠和细胞模型中，使用CRMP3抗体分析其表达模式，发现其在神经发育期高表达，而在神经退行性疾病模型中显著下调，可能与突触可塑性受损有关。
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如需具体文献全文，建议通过PubMed或Google Scholar检索标题或作者名获取详细信息。
CRMP3 (Collapsin Response Mediator Protein 3), also known as DPYSL4. is a member of the CRMP family of cytosolic phosphoproteins primarily expressed in the nervous system. These proteins play critical roles in neuronal development, including axon guidance, dendritic patterning, and synaptic plasticity by regulating microtubule dynamics and intracellular signaling pathways. CRMP3 interacts with tubulin heterodimers to promote microtubule assembly, influencing neurite outgrowth and neuronal polarity. It is particularly abundant in the developing brain but remains expressed in specific regions of the adult brain, such as the hippocampus and cerebellum.
CRMP3 antibodies are widely used as research tools to study its expression, localization, and function in neurological processes. Dysregulation of CRMP3 has been implicated in neurodevelopmental disorders, neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions. For example, reduced CRMP3 levels correlate with synaptic deficits in Alzheimer’s models. Antibodies against CRMP3 also help investigate its role in cancer, where aberrant expression is observed in glioblastoma and neuroblastoma.
These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to explore CRMP3's involvement in Semaphorin 3A signaling and its cross-talk with pathways like GSK-3β. Their specificity and reliability make them valuable for deciphering CRMP3’s contributions to both physiological and pathological states.
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