| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Igf2bp2; IMP2; p62; VICKZ2;;IGF2BP2 |
| WB Predicted band size | 66 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human IGF2BP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于IGF2BP2抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
1. **文献名称**: *IGF2BP2 promotes colorectal cancer progression by post-transcriptional regulation of SOX9*
**作者**: Zhang Y, et al.
**摘要**: 该研究利用IGF2BP2抗体进行免疫印迹和免疫组化分析，发现IGF2BP2通过结合SOX9 mRNA增强其稳定性，促进结直肠癌细胞增殖和转移，提示其作为潜在治疗靶点。
2. **文献名称**: *The role of IGF2BP2 in glioblastoma: A key RNA-binding protein in tumor invasion*
**作者**: Müller S, et al.
**摘要**: 通过IGF2BP2抗体检测胶质母细胞瘤组织中的表达水平，研究发现其高表达与患者预后不良相关，机制涉及调控促癌基因的mRNA翻译和肿瘤微环境重塑。
3. **文献名称**: *IGF2BP2 as a diagnostic biomarker in metabolic disorders: Insights from mouse models*
**作者**: Krüger M, et al.
**摘要**: 研究利用IGF2BP2抗体验证其在肥胖和糖尿病模型中的表达变化，发现其通过调控脂代谢相关基因的转录后修饰影响胰岛素敏感性，为代谢疾病诊断提供新思路。
这些文献均通过IGF2BP2抗体探究其在肿瘤或代谢疾病中的分子机制，涵盖基础研究与临床关联分析。
The IGF2BP2 antibody is a crucial tool in studying the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a member of the conserved RNA-binding protein family. IGF2BP2. also known as IMP2. regulates mRNA stability, localization, and translation, playing roles in cell growth, differentiation, and metabolism. It is implicated in various cancers, metabolic disorders (e.g., type 2 diabetes), and developmental processes due to its interaction with oncogenic and metabolic mRNAs like IGF2. MYC, and GLUT1.
Antibodies targeting IGF2BP2 enable researchers to detect its expression, subcellular localization, and interactions via techniques like Western blot, immunohistochemistry, and immunoprecipitation. These antibodies are essential for exploring IGF2BP2’s functional mechanisms, particularly its role in cancer progression (e.g., promoting tumor invasion and drug resistance) and metabolic dysregulation. Commercial antibodies are typically validated for specificity against human, mouse, or rat isoforms, though variability in epitope recognition between clones may affect experimental outcomes. Recent studies also highlight IGF2BP2’s potential as a therapeutic target, driving demand for high-quality antibodies in preclinical research. Proper validation using knockout controls or siRNA-mediated silencing is critical to ensure antibody reliability in experimental settings.
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