| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HCAK1; IGKC; IGKCD;;Human Ig kappa light chain |
| WB Predicted band size | Calculated MW: 12 kDa ; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Human Ig kappa light chain |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于kappa轻链(κ light chain)抗体的参考文献示例(内容为示例，非真实文献)：
1. **文献名称**：*Structural insights into κ light chain antibody diversity*
**作者**：Smith J, et al.
**摘要**：通过X射线晶体学解析κ轻链抗体的可变区结构，揭示了其多样性形成的分子机制，为抗体工程优化提供理论基础。
2. **文献名称**：*κ light chain deposition in renal diseases: diagnostic implications*
**作者**：Lee H, et al.
**摘要**：探讨κ轻链在肾脏病中的异常沉积机制，提出通过检测血清游离κ轻链水平辅助诊断轻链沉积病的临床价值。
3. **文献名称**：*Targeting κ light chain for B-cell malignancy therapy*
**作者**：Garcia R, et al.
**摘要**：开发靶向κ轻链的单克隆抗体，在体外和小鼠模型中验证其对表达κ轻链的B细胞淋巴瘤的特异性杀伤作用。
4. **文献名称**：*κ/λ light chain ratio as a biomarker in multiple myeloma*
**作者**：Wang Y, et al.
**摘要**：分析κ/λ轻链比值在多发性骨髓瘤中的诊断及预后意义，证实其与疾病进展和治疗反应的相关性。
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**备注**：以上文献为示例，实际文献需通过PubMed、Web of Science等平台检索关键词(如“kappa light chain antibody”、“immunoglobulin light chain”)。如需具体文献，建议提供研究背景以缩小范围。
The kappa light chain antibody is a critical component of immunoglobulin molecules, specifically targeting the kappa-type light chains found in antibodies. Antibodies, or immunoglobulins, consist of two heavy chains and two light chains, with light chains existing as either kappa (κ) or lambda (λ) subtypes. Approximately 60% of human antibodies contain kappa light chains, encoded by the IGK gene locus on chromosome 2. These chains contribute to antigen-binding specificity by pairing with heavy chains to form the variable region, which recognizes diverse pathogens.
Kappa light chain antibodies are widely used in research and diagnostics to identify B-cell clonality, as abnormal proliferation of B-cells (e.g., in lymphomas or multiple myeloma) often results in monoclonal overproduction of either κ or λ chains. Detection of restricted light chain expression via techniques like flow cytometry or immunohistochemistry aids in diagnosing malignancies. Additionally, free kappa light chains in serum or urine serve as biomarkers for conditions like light chain amyloidosis or kidney disorders.
Therapeutic applications include targeting κ-expressing B-cells in autoimmune diseases. Notably, κ light chain antibodies are essential tools in understanding B-cell development, immune responses, and disease mechanisms, underscoring their significance in both basic and clinical immunology.
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