| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EMT; EMTH; OCT3; Orct3; Slc22a3;;SLC22A3 |
| WB Predicted band size | Calculated MW: 61 kDa ; Observed MW: 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SLC22A3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于SLC22A3抗体的模拟参考文献示例(内容为虚构，仅作格式参考)：
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1. **文献名称**：*Characterization of SLC22A3 Antibody Specificity in Breast Cancer Tissue*
**作者**：Zhang L, et al.
**摘要**：本研究验证了一种高特异性SLC22A3抗体在乳腺癌组织中的适用性。通过免疫组化和Western blot分析，发现SLC22A3在肿瘤基质中显著低表达，且其表达水平与患者生存率呈正相关，提示其作为预后标志物的潜力。
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2. **文献名称**：*SLC22A3 Polymorphisms Affect Antibody Binding Efficiency in Pharmacogenetic Studies*
**作者**：Smith JR, Patel K.
**摘要**：探讨SLC22A3基因多态性对抗体检测蛋白表达的影响。研究发现某些单核苷酸多态性(SNPs)会导致抗体结合效率下降，提示在临床检测中需结合基因分型以提高准确性。
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3. **文献名称**：*Development of a Novel Monoclonal Antibody for SLC22A3 Transport Function Analysis*
**作者**：Tanaka H, et al.
**摘要**：报道一种新型抗SLC22A3单克隆抗体的开发与验证。通过体外转运实验和免疫荧光共定位，证实该抗体可有效阻断SLC22A3介导的有机阳离子转运，为药物相互作用研究提供工具。
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注：以上文献为模拟内容，实际引用需检索PubMed或Google Scholar等数据库获取真实信息。
The SLC22A3 antibody targets the solute carrier family 22 member 3 (SLC22A3), a protein encoded by the SLC22A3 gene, which belongs to the organic cation transporter (OCT) family. SLC22A3. also known as OCT3. is a polyspecific transporter involved in the cellular uptake and efflux of various endogenous compounds (e.g., dopamine, norepinephrine, histamine) and exogenous drugs (e.g., metformin, cisplatin). It plays critical roles in neurotransmitter clearance, metabolic regulation, and drug disposition across tissues like the liver, kidney, placenta, and brain.
Antibodies against SLC22A3/OCT3 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate its role in diseases like cancer (e.g., modulating chemotherapeutic response), cardiovascular disorders, and diabetes. Specificity and validation of these antibodies are crucial, as cross-reactivity with other OCT isoforms (e.g., OCT1. OCT2) may occur. Both polyclonal and monoclonal SLC22A3 antibodies are available, with applications spanning basic research to clinical biomarker studies. Recent studies also explore its involvement in neurological conditions, highlighting its therapeutic and diagnostic potential. Proper controls, such as knockout validation, are recommended to ensure antibody reliability.
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